SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hn9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 11 SER A 316
VAL A 313
TYR A 231
GLU A 166
GLU A  99
 None
 1.49A 1fdtA-4hn9A:
undetectable		 1fdtA-4hn9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 5 LEU A  91
ALA A  88
LEU A  86
SER A  82
 None
 1.14A 1tt6B-4hn9A:
undetectable		 1tt6B-4hn9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 5 ILE A 158
LEU A 142
ALA A 150
GLU A 154
 None
 0.99A 1xvaA-4hn9A:
undetectable
1xvaB-4hn9A:
undetectable		 1xvaA-4hn9A:
22.10
1xvaB-4hn9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 6 ALA A 150
GLU A 154
ILE A 158
LEU A 142
 None
 0.97A 1xvaA-4hn9A:
undetectable
1xvaB-4hn9A:
undetectable		 1xvaA-4hn9A:
22.10
1xvaB-4hn9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 11 GLY A 315
SER A 316
GLU A 307
LEU A 235
ILE A 306
 None
 1.49A 2a58A-4hn9A:
3.6
2a58E-4hn9A:
3.6		 2a58A-4hn9A:
20.00
2a58E-4hn9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 11 ILE A 306
GLY A 315
SER A 316
GLU A 307
LEU A 235
 None
 1.49A 2a58C-4hn9A:
2.4
2a58D-4hn9A:
2.2		 2a58C-4hn9A:
20.00
2a58D-4hn9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 5 ASP A  93
GLY A 350
PRO A 113
ALA A 114
 None
 0.77A 2aofA-4hn9A:
undetectable		 2aofA-4hn9A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 10 LEU A  95
VAL A 139
ILE A 181
GLY A 179
ILE A  75
 None
 1.05A 3oxwB-4hn9A:
undetectable		 3oxwB-4hn9A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 6 LEU A 288
LEU A 262
GLU A 259
TYR A 258
 None
 1.20A 4f3tA-4hn9A:
2.6		 4f3tA-4hn9A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 11 LEU A  95
VAL A 139
ILE A 181
GLY A 179
ILE A  75
 None
 0.95A 4rvjA-4hn9A:
undetectable		 4rvjA-4hn9A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 11 LEU A  95
VAL A 139
ILE A 181
GLY A 179
ILE A  75
 None
 0.96A 4rvjC-4hn9A:
undetectable		 4rvjC-4hn9A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 12 THR A 176
ALA A 188
LEU A 191
LEU A  89
PRO A 314
 None
 1.22A 4xi3D-4hn9A:
undetectable		 4xi3D-4hn9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 12 TYR A  80
SER A  84
ILE A 107
TRP A 309
VAL A 341
 None
 1.22A 5h1eA-4hn9A:
undetectable		 5h1eA-4hn9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 8 ILE A 181
PRO A  72
MET A 121
ILE A 158
 None
 0.84A 5ieoA-4hn9A:
undetectable		 5ieoA-4hn9A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_A_K1SA304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 5 GLU A 307
TRP A 309
VAL A 313
LEU A 235
 None
 1.26A 5qjqA-4hn9A:
0.0
5qjqB-4hn9A:
0.0		 5qjqA-4hn9A:
22.02
5qjqB-4hn9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 5 TRP A 309
VAL A 313
LEU A 235
GLU A 307
 None
 1.26A 5qjqA-4hn9A:
0.0
5qjqB-4hn9A:
0.0		 5qjqA-4hn9A:
22.02
5qjqB-4hn9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_C_K1SC305_0
(ADP-SUGAR
PYROPHOSPHATASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		4 / 5 GLU A 307
TRP A 309
VAL A 313
LEU A 235
 None
 1.25A 5qjqC-4hn9A:
0.0
5qjqD-4hn9A:
0.0		 5qjqC-4hn9A:
22.02
5qjqD-4hn9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4hn9 IRON COMPLEX
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
([Eubacterium]
eligens) 		5 / 12 TYR A 349
ALA A 190
ALA A 188
LEU A  85
ILE A  81
 None
 1.18A 6aybA-4hn9A:
undetectable		 6aybA-4hn9A:
19.59