SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 7 GLN A 261
GLU A 193
PHE A 364
ALA A 343
 GLN  A 261 (-0.6A)
GLU  A 193 ( 0.5A)
PHE  A 364 ( 1.3A)
ALA  A 343 ( 0.0A)
 1.36A 1linA-4hneA:
undetectable		 1linA-4hneA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 4 ASP A 301
ASP A 200
ASP A 346
GLY A 195
 ASP  A 301 ( 0.6A)
ASP  A 200 ( 0.6A)
ASP  A 346 (-0.6A)
GLY  A 195 ( 0.0A)
 1.36A 2igtC-4hneA:
undetectable		 2igtC-4hneA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		3 / 3 LYS A 256
TYR A 138
PRO A 153
 LYS  A 256 ( 0.0A)
TYR  A 138 ( 1.3A)
PRO  A 153 ( 1.1A)
 1.30A 2j9cC-4hneA:
undetectable		 2j9cC-4hneA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 350
GLN A 426
ASP A 182
PRO A 356
LEU A 184
 ALA  A 350 ( 0.0A)
GLN  A 426 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 356 ( 1.1A)
LEU  A 184 ( 0.6A)
 1.32A 2nv4A-4hneA:
undetectable		 2nv4A-4hneA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 6 LEU A 297
LEU A 300
ASP A 301
TRP A 366
 LEU  A 297 ( 0.5A)
LEU  A 300 ( 0.5A)
ASP  A 301 ( 0.6A)
TRP  A 366 ( 0.5A)
 1.08A 2rlfB-4hneA:
undetectable
2rlfC-4hneA:
undetectable		 2rlfB-4hneA:
7.42
2rlfC-4hneA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 7 LEU A 282
GLU A 280
ILE A 340
ILE A 345
 LEU  A 282 ( 0.6A)
GLU  A 280 ( 0.6A)
ILE  A 340 ( 0.6A)
ILE  A 345 (-0.5A)
 0.85A 2xkwA-4hneA:
undetectable		 2xkwA-4hneA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 6 GLU A 157
ASN A 187
SER A 259
PHE A 151
 GLU  A 157 ( 0.5A)
ASN  A 187 ( 0.6A)
SER  A 259 ( 0.0A)
PHE  A 151 ( 1.3A)
 1.49A 3i9jB-4hneA:
undetectable		 3i9jB-4hneA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 7 ASN A 249
ALA A 237
ALA A  97
ARG A 101
 ASN  A 249 ( 0.6A)
ALA  A 237 ( 0.0A)
ALA  A  97 ( 0.0A)
ARG  A 101 ( 0.6A)
 0.80A 3twpA-4hneA:
undetectable		 3twpA-4hneA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 7 ASN A 249
ALA A 237
ALA A  97
ARG A 101
 ASN  A 249 ( 0.6A)
ALA  A 237 ( 0.0A)
ALA  A  97 ( 0.0A)
ARG  A 101 ( 0.6A)
 0.75A 3twpB-4hneA:
undetectable		 3twpB-4hneA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 7 ASN A 249
ALA A 237
ALA A  97
ARG A 101
 ASN  A 249 ( 0.6A)
ALA  A 237 ( 0.0A)
ALA  A  97 ( 0.0A)
ARG  A 101 ( 0.6A)
 0.76A 3twpC-4hneA:
undetectable		 3twpC-4hneA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		5 / 12 ILE A 304
ASP A 301
VAL A 342
ASP A 200
ILE A 207
 ILE  A 304 ( 0.6A)
ASP  A 301 ( 0.6A)
VAL  A 342 ( 0.5A)
ASP  A 200 ( 0.6A)
ILE  A 207 ( 0.6A)
 1.36A 4i41A-4hneA:
6.5		 4i41A-4hneA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 221
ILE A 121
PHE A 260
ASN A 102
 PHE  A 221 ( 1.3A)
ILE  A 121 ( 0.7A)
PHE  A 260 ( 1.3A)
ASN  A 102 ( 0.6A)
 1.47A 4o7gB-4hneA:
undetectable		 4o7gB-4hneA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 203
LEU A 385
ILE A 427
LEU A 430
LEU A 397
 LEU  A 203 ( 0.5A)
LEU  A 385 ( 0.6A)
ILE  A 427 ( 0.7A)
LEU  A 430 ( 0.6A)
LEU  A 397 ( 0.5A)
 1.02A 4odoA-4hneA:
undetectable		 4odoA-4hneA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 203
LEU A 385
ILE A 427
LEU A 430
LEU A 397
 LEU  A 203 ( 0.5A)
LEU  A 385 ( 0.6A)
ILE  A 427 ( 0.7A)
LEU  A 430 ( 0.6A)
LEU  A 397 ( 0.5A)
 1.02A 4odoB-4hneA:
undetectable		 4odoB-4hneA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 203
LEU A 385
ILE A 427
LEU A 430
LEU A 397
 LEU  A 203 ( 0.5A)
LEU  A 385 ( 0.6A)
ILE  A 427 ( 0.7A)
LEU  A 430 ( 0.6A)
LEU  A 397 ( 0.5A)
 1.04A 4odoC-4hneA:
undetectable		 4odoC-4hneA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		3 / 3 PRO A 283
LEU A 282
GLN A 289
 PRO  A 283 ( 1.1A)
LEU  A 282 ( 0.6A)
GLN  A 289 ( 0.6A)
 0.58A 4pevB-4hneA:
undetectable		 4pevB-4hneA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		5 / 12 PHE A 416
PHE A 405
GLN A 419
ILE A 420
VAL A 199
 PHE  A 416 ( 1.3A)
PHE  A 405 ( 1.3A)
GLN  A 419 ( 0.6A)
ILE  A 420 ( 0.7A)
VAL  A 199 ( 0.6A)
 1.50A 4yfbF-4hneA:
undetectable		 4yfbF-4hneA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		5 / 12 PHE A 416
PHE A 405
GLN A 419
ILE A 420
VAL A 199
 PHE  A 416 ( 1.3A)
PHE  A 405 ( 1.3A)
GLN  A 419 ( 0.6A)
ILE  A 420 ( 0.7A)
VAL  A 199 ( 0.6A)
 1.49A 4yfbI-4hneA:
undetectable		 4yfbI-4hneA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		5 / 12 PHE A 416
PHE A 405
GLN A 419
ILE A 420
VAL A 199
 PHE  A 416 ( 1.3A)
PHE  A 405 ( 1.3A)
GLN  A 419 ( 0.6A)
ILE  A 420 ( 0.7A)
VAL  A 199 ( 0.6A)
 1.48A 4yfbL-4hneA:
undetectable		 4yfbL-4hneA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 8 PHE A 110
ARG A 115
ALA A 117
PHE A 260
 PHE  A 110 ( 1.3A)
ARG  A 115 ( 0.6A)
ALA  A 117 ( 0.0A)
PHE  A 260 ( 1.3A)
 1.05A 5m0oC-4hneA:
undetectable		 5m0oC-4hneA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 6 ASN A 206
VAL A 342
LEU A 315
GLN A 293
 ASN  A 206 ( 0.6A)
VAL  A 342 ( 0.5A)
LEU  A 315 ( 0.5A)
GLN  A 293 ( 0.6A)
 1.07A 5xdhA-4hneA:
undetectable
5xdhC-4hneA:
undetectable		 5xdhA-4hneA:
11.94
5xdhC-4hneA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		4 / 6 GLN A 293
ASN A 206
VAL A 342
LEU A 315
 GLN  A 293 ( 0.6A)
ASN  A 206 ( 0.6A)
VAL  A 342 ( 0.5A)
LEU  A 315 ( 0.5A)
 1.08A 5xdhA-4hneA:
undetectable
5xdhC-4hneA:
undetectable		 5xdhA-4hneA:
11.94
5xdhC-4hneA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens) 		3 / 3 ARG A 210
LEU A 262
PHE A 263
 ARG  A 210 ( 0.6A)
LEU  A 262 (-0.5A)
PHE  A 263 (-1.3A)
 0.61A 6nknP-4hneA:
undetectable		 6nknP-4hneA:
18.09