SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hnh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		5 / 11 LEU A  32
MET A  28
LEU A  22
VAL A  73
ILE A   7
 None
 1.20A 1ee2B-4hnhA:
5.4		 1ee2B-4hnhA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		4 / 4 HIS A  48
VAL A  51
THR A  24
LEU A  18
 None
 1.45A 1oq5A-4hnhA:
undetectable		 1oq5A-4hnhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		5 / 12 LEU A  64
GLN A  66
ALA A  67
THR A  31
THR A   6
 None
 1.13A 3a35A-4hnhA:
undetectable		 3a35A-4hnhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		5 / 12 LEU A  64
GLN A  66
ALA A  67
THR A  31
THR A   6
 None
 1.15A 3a35B-4hnhA:
undetectable		 3a35B-4hnhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		5 / 12 LEU A  64
GLN A  66
ALA A  67
THR A  31
THR A   6
 None
 1.11A 3a3bA-4hnhA:
undetectable		 3a3bA-4hnhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		5 / 9 PHE A  58
GLY A  12
ALA A  15
THR A  19
ILE A   5
 NAP  A 301 (-3.6A)
NAP  A 301 (-3.1A)
None
None
None
 1.41A 3jusB-4hnhA:
undetectable		 3jusB-4hnhA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		4 / 6 ARG A  40
ILE A  46
VAL A  53
LEU A  32
 NAP  A 301 (-3.0A)
None
None
None
 1.11A 4em2A-4hnhA:
undetectable		 4em2A-4hnhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		5 / 12 GLY A   9
LEU A  37
THR A  19
ILE A  30
VAL A  51
 NAP  A 301 ( 3.9A)
None
None
None
None
 0.94A 4ok1A-4hnhA:
undetectable		 4ok1A-4hnhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		5 / 9 LEU A 151
GLY A 102
VAL A 182
VAL A 205
LEU A 165
 NAP  A 301 ( 4.4A)
None
None
None
None
 1.16A 4qd3A-4hnhA:
3.0		 4qd3A-4hnhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Veillonella
parvula) 		3 / 3 ARG A  99
PHE A 187
PHE A 198
 None
FMT  A 307 ( 3.9A)
None
 0.92A 6nknC-4hnhA:
undetectable
6nknJ-4hnhA:
undetectable		 6nknC-4hnhA:
20.69
6nknJ-4hnhA:
14.48