SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 8 LYS A  35
THR A  36
GLY A  68
LEU A  84
 None
None
KPI  A 184 ( 3.5A)
None
 0.74A 1aegA-4hnnA:
undetectable		 1aegA-4hnnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 9 VAL A  98
GLY A 100
THR A 114
THR A 102
ILE A  85
 None
 1.22A 1gtnL-4hnnA:
undetectable
1gtnM-4hnnA:
undetectable		 1gtnL-4hnnA:
13.64
1gtnM-4hnnA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 8 ASP A  59
ILE A 302
GLY A 303
GLY A 309
 None
 0.74A 1me7A-4hnnA:
4.2		 1me7A-4hnnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 GLY A 221
ILE A  25
GLY A 182
VAL A 183
ILE A  31
 None
None
None
KPI  A 184 ( 2.9A)
None
 0.92A 2avsB-4hnnA:
undetectable		 2avsB-4hnnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 ASN A 101
GLY A 103
PHE A 144
ALA A 125
THR A 153
 None
 0.95A 2axnA-4hnnA:
undetectable		 2axnA-4hnnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 11 ILE A 166
ILE A 171
GLY A 103
LEU A 148
PHE A 144
 None
 1.21A 2azyA-4hnnA:
undetectable		 2azyA-4hnnA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 7 TYR A 156
GLY A  68
THR A  69
ASN A 101
 KPI  A 184 ( 3.8A)
KPI  A 184 ( 3.5A)
KPI  A 184 ( 4.3A)
None
 1.07A 2g70B-4hnnA:
undetectable		 2g70B-4hnnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 5 VAL A  89
THR A  88
VAL A  66
GLY A 100
 None
 1.15A 2p2fA-4hnnA:
undetectable		 2p2fA-4hnnA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 4 VAL A  89
THR A  88
VAL A  66
GLY A 100
 None
 1.17A 2p2fB-4hnnA:
undetectable		 2p2fB-4hnnA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 LEU A 270
PRO A 263
THR A  70
GLY A  71
GLY A  67
 None
None
KPI  A 184 ( 3.8A)
None
None
 1.12A 2uvnA-4hnnA:
undetectable		 2uvnA-4hnnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 6 PRO A 252
ILE A 230
ASN A 247
LEU A 237
 None
 0.99A 2wekB-4hnnA:
2.1		 2wekB-4hnnA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		3 / 3 ASP A 318
PHE A 321
LEU A 323
 None
 0.54A 2zi9A-4hnnA:
undetectable		 2zi9A-4hnnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 LEU A 257
MET A 234
ILE A 302
VAL A 313
LEU A 273
 None
 1.12A 3a51C-4hnnA:
undetectable		 3a51C-4hnnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		3 / 3 ASN A 262
ASP A 208
GLN A 209
 None
 0.84A 3eeyC-4hnnA:
undetectable		 3eeyC-4hnnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		3 / 3 ASN A 262
ASP A 208
GLN A 209
 None
 0.83A 3eeyE-4hnnA:
undetectable		 3eeyE-4hnnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 5 PRO A 159
VAL A 187
THR A 173
GLY A 169
 None
 1.06A 3elzB-4hnnA:
undetectable		 3elzB-4hnnA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 GLY A 221
ILE A  25
GLY A 182
VAL A 183
ILE A  31
 None
None
None
KPI  A 184 ( 2.9A)
None
 0.95A 3nu5B-4hnnA:
undetectable		 3nu5B-4hnnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 GLY A 221
ILE A  25
GLY A 182
VAL A 183
ILE A  31
 None
None
None
KPI  A 184 ( 2.9A)
None
 0.87A 3oxxC-4hnnA:
undetectable		 3oxxC-4hnnA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 9 LEU A 266
ASN A 262
VAL A 254
GLY A 205
ILE A 223
 None
None
None
KPI  A 184 ( 4.3A)
KPI  A 184 ( 3.5A)
 1.23A 3spkA-4hnnA:
undetectable		 3spkA-4hnnA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 7 PHE A 295
THR A 226
ILE A 230
PHE A 307
 None
 0.87A 4ejjA-4hnnA:
undetectable		 4ejjA-4hnnA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 8 GLY A  68
GLY A 100
VAL A 154
TYR A 156
 KPI  A 184 ( 3.5A)
None
None
KPI  A 184 ( 3.8A)
 0.71A 4fgzB-4hnnA:
undetectable		 4fgzB-4hnnA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		3 / 3 ARG A 108
HIS A 112
SER A 106
 None
 0.83A 4mjwA-4hnnA:
undetectable
4mjwB-4hnnA:
undetectable		 4mjwA-4hnnA:
21.38
4mjwB-4hnnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		3 / 3 SER A 106
ARG A 108
HIS A 112
 None
 0.87A 4mjwA-4hnnA:
undetectable
4mjwB-4hnnA:
undetectable		 4mjwA-4hnnA:
21.38
4mjwB-4hnnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 VAL A  66
SER A  95
PHE A  92
ASP A  50
GLY A  93
 None
 1.37A 4pevA-4hnnA:
1.3		 4pevA-4hnnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 VAL A  66
SER A  95
PHE A  92
ASP A  50
GLY A  93
 None
 1.38A 4pevB-4hnnA:
undetectable		 4pevB-4hnnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 VAL A 315
GLN A 272
LEU A 229
ASN A 297
GLY A 303
 None
 1.18A 4qckA-4hnnA:
undetectable		 4qckA-4hnnA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 PRO A 231
TYR A  49
THR A  70
ASN A 262
ILE A  34
 None
None
KPI  A 184 ( 3.8A)
None
None
 1.37A 4xe0A-4hnnA:
undetectable		 4xe0A-4hnnA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		5 / 12 GLY A 151
ALA A 125
ALA A 110
ILE A 111
ALA A 178
 None
 1.08A 5bw4B-4hnnA:
undetectable		 5bw4B-4hnnA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 5 HIS A 127
HIS A 143
VAL A 147
ALA A 110
 None
 1.29A 5i3bB-4hnnA:
undetectable		 5i3bB-4hnnA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4hnn DIHYDRODIPICOLINATE
SYNTHASE
(Vitis
vinifera) 		4 / 6 ASP A 312
ASP A 317
ARG A 292
GLN A 272
 None
 1.30A 5l6eA-4hnnA:
1.9		 5l6eA-4hnnA:
20.99