SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4hns CHEMOTAXIS PROTEIN
CHEY
(Vibrio
cholerae) 		4 / 5 ALA A 101
TRP A  61
LEU A  71
ALA A 104
 None
 1.08A 2jstA-4hnsA:
undetectable
2jstB-4hnsA:
undetectable		 2jstA-4hnsA:
21.19
2jstB-4hnsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4hns CHEMOTAXIS PROTEIN
CHEY
(Vibrio
cholerae) 		4 / 7 ILE A 110
ILE A 126
LEU A  28
VAL A  24
 None
 0.88A 3ua5B-4hnsA:
undetectable		 3ua5B-4hnsA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4hns CHEMOTAXIS PROTEIN
CHEY
(Vibrio
cholerae) 		5 / 12 PHE A  54
ASP A  70
GLU A 100
ALA A 101
TYR A 109
 None
 1.09A 4pclA-4hnsA:
2.6		 4pclA-4hnsA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4hns CHEMOTAXIS PROTEIN
CHEY
(Vibrio
cholerae) 		4 / 8 ASP A  16
ASP A  60
ASP A  15
ILE A 110
 MG  A 201 (-2.6A)
BEF  A 202 ( 2.0A)
MG  A 201 ( 4.3A)
None
 1.03A 4xjeA-4hnsA:
undetectable		 4xjeA-4hnsA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4hns CHEMOTAXIS PROTEIN
CHEY
(Vibrio
cholerae) 		4 / 8 ASP A  16
ASP A  60
ASP A  15
ILE A 110
 MG  A 201 (-2.6A)
BEF  A 202 ( 2.0A)
MG  A 201 ( 4.3A)
None
 1.00A 5cfsA-4hnsA:
undetectable		 5cfsA-4hnsA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4hns CHEMOTAXIS PROTEIN
CHEY
(Vibrio
cholerae) 		4 / 6 ALA A  91
THR A  90
VAL A 111
TYR A 109
 BEF  A 202 (-3.8A)
BEF  A 202 (-3.4A)
None
None
 0.92A 5ecoA-4hnsA:
2.9		 5ecoA-4hnsA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4hns CHEMOTAXIS PROTEIN
CHEY
(Vibrio
cholerae) 		5 / 11 PHE A  33
ILE A 126
ILE A 110
ILE A  89
PHE A  56
 None
 1.23A 5hw8E-4hnsA:
undetectable		 5hw8E-4hnsA:
21.05