SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ho4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 5 ALA A 203
ILE A 187
ILE A 197
ASP A 199
 None
 1.05A 2h4jA-4ho4A:
undetectable		 2h4jA-4ho4A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 7 THR A 224
TYR A 174
PHE A 111
LEU A  86
 None
None
None
G1P  A 301 ( 4.9A)
 1.03A 2hzqA-4ho4A:
undetectable		 2hzqA-4ho4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 5 TYR A 256
ALA A 270
TYR A  35
MET A  42
 None
 1.09A 3d91A-4ho4A:
undetectable		 3d91A-4ho4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 5 SER A  53
GLY A  85
GLU A 159
GLU A 196
 None
THM  A 302 (-3.6A)
G1P  A 301 (-2.8A)
None
 1.39A 3raeB-4ho4A:
undetectable
3raeD-4ho4A:
undetectable		 3raeB-4ho4A:
22.63
3raeD-4ho4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 9 ALA A 184
ILE A  97
GLY A  93
ILE A  92
LEU A  86
 None
None
None
None
G1P  A 301 ( 4.9A)
 1.08A 3u7sA-4ho4A:
undetectable		 3u7sA-4ho4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 12 SER A 167
TYR A 135
ASP A 108
ASP A 139
SER A 229
 None
None
THM  A 302 (-3.5A)
None
None
 1.21A 3v8vB-4ho4A:
undetectable		 3v8vB-4ho4A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 9 GLY A 172
LEU A  41
ASP A 108
LEU A 106
ILE A   5
 G1P  A 301 ( 4.2A)
None
THM  A 302 (-3.5A)
THM  A 302 (-4.2A)
None
 1.22A 3wdmC-4ho4A:
undetectable		 3wdmC-4ho4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 10 GLY A 172
LEU A  41
ASP A 108
LEU A 106
ILE A   5
 G1P  A 301 ( 4.2A)
None
THM  A 302 (-3.5A)
THM  A 302 (-4.2A)
None
 1.17A 3wdmD-4ho4A:
undetectable		 3wdmD-4ho4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 7 VAL A 200
PHE A  90
VAL A 102
ILE A 132
 None
 0.94A 3zjqA-4ho4A:
undetectable		 3zjqA-4ho4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 7 VAL A 200
PHE A  90
VAL A 102
ILE A 132
 None
 0.94A 3zjqB-4ho4A:
undetectable		 3zjqB-4ho4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 9 LEU A 104
ILE A   4
ILE A   5
TYR A  35
ILE A  52
 None
 0.95A 3zosA-4ho4A:
undetectable		 3zosA-4ho4A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 12 GLY A 134
VAL A 180
TYR A 176
ASN A 201
VAL A 200
 None
 1.45A 4ffwA-4ho4A:
undetectable		 4ffwA-4ho4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		3 / 3 SER A  76
ALA A  78
VAL A  79
 None
 0.52A 4x1iA-4ho4A:
undetectable		 4x1iA-4ho4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 12 ILE A 183
ALA A  87
LYS A 202
ILE A 132
LEU A 210
 None
 1.07A 4x5gA-4ho4A:
undetectable		 4x5gA-4ho4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 12 ILE A 183
ALA A  87
LYS A 202
ILE A 132
LEU A 210
 None
 1.10A 4x5hA-4ho4A:
undetectable		 4x5hA-4ho4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		4 / 6 GLN A 121
PHE A 175
LEU A 173
PHE A 111
 None
 1.15A 5b1bC-4ho4A:
undetectable
5b1bJ-4ho4A:
undetectable		 5b1bC-4ho4A:
22.36
5b1bJ-4ho4A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		3 / 3 SER A  76
ALA A  78
VAL A  79
 None
 0.56A 5eypA-4ho4A:
undetectable		 5eypA-4ho4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 12 ALA A  87
PHE A  96
GLY A  98
GLY A   3
VAL A 102
 None
 1.01A 5i71A-4ho4A:
undetectable		 5i71A-4ho4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 12 ALA A  87
PHE A  96
GLY A  98
GLY A   3
VAL A 102
 None
 0.95A 5i73A-4ho4A:
undetectable		 5i73A-4ho4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 12 GLU A 159
LEU A 195
GLY A  85
ILE A 187
ALA A 184
 G1P  A 301 (-2.8A)
None
THM  A 302 (-3.6A)
None
None
 0.93A 5j7wD-4ho4A:
undetectable		 5j7wD-4ho4A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		3 / 3 ASP A  99
ASN A 178
ASP A 182
 None
 0.82A 5vopA-4ho4A:
undetectable		 5vopA-4ho4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_2
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		5 / 9 GLN A  88
GLN A  80
ASP A 108
GLY A 193
SER A 190
 None
THM  A 302 (-3.0A)
THM  A 302 (-3.5A)
None
None
 1.47A 5x7pB-4ho4A:
0.4		 5x7pB-4ho4A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Aneurinibacillus
thermoaerophilus) 		3 / 3 SER A  76
ALA A  78
VAL A  79
 None
 0.54A 5xiwC-4ho4A:
undetectable		 5xiwC-4ho4A:
14.29