SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hoj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 1jffB-4hojA:
undetectable		 1jffB-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 PHE A  18
TYR A 178
TYR A 141
 None
 0.89A 1x70B-4hojA:
undetectable		 1x70B-4hojA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 2hxfB-4hojA:
undetectable		 2hxfB-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 2hxhB-4hojA:
undetectable		 2hxhB-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 2p4nB-4hojA:
undetectable		 2p4nB-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 2wbeB-4hojA:
undetectable		 2wbeB-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 3dcoB-4hojA:
undetectable		 3dcoB-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 3edlB-4hojA:
undetectable		 3edlB-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
LEU A 158
LEU A 175
ARG A 185
GLY A 144
 ACT  A 303 (-3.9A)
None
None
None
None
 0.98A 3iz0B-4hojA:
undetectable		 3iz0B-4hojA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 9 LEU A 161
VAL A 166
LEU A 101
ILE A 125
PHE A 102
 None
None
ACT  A 303 ( 4.9A)
None
None
 1.07A 3tbgD-4hojA:
undetectable		 3tbgD-4hojA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 ASN A  64
ALA A 153
ARG A  15
 None
 0.90A 3tj7C-4hojA:
undetectable
3tj7D-4hojA:
undetectable		 3tj7C-4hojA:
19.21
3tj7D-4hojA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 PHE A  12
ARG A  15
PRO A  51
SER A  63
 GSH  A 302 (-3.8A)
None
GSH  A 302 (-4.2A)
GSH  A 302 (-2.7A)
 0.37A 3vlnA-4hojA:
21.5		 3vlnA-4hojA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 PHE A  12
PRO A  51
GLU A  62
SER A  63
 GSH  A 302 (-3.8A)
GSH  A 302 (-4.2A)
GSH  A 302 (-2.8A)
GSH  A 302 (-2.7A)
 0.66A 3vlnA-4hojA:
21.5		 3vlnA-4hojA:
29.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 5 VAL A  93
ARG A  96
MET A  97
GLU A 100
LEU A 132
 ACT  A 303 (-3.9A)
ACT  A 303 (-3.7A)
ACT  A 303 (-4.7A)
ACT  A 303 (-4.2A)
ACT  A 303 (-4.7A)
 0.01A 4hojA-4hojA:
38.3		 4hojA-4hojA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 150
ALA A 153
ARG A  15
MET A  97
ASN A  64
 None
None
None
ACT  A 303 (-4.7A)
None
 1.08A 4zo1X-4hojA:
undetectable		 4zo1X-4hojA:
24.25