SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hoo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		5 / 12 ILE A  18
ALA A  43
GLN A 266
ILE A  52
PRO A  53
 None
 1.00A 1dhfA-4hooA:
undetectable		 1dhfA-4hooA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		5 / 12 PHE A 182
GLY A 183
LEU A 144
LEU A 206
TYR A  63
 None
 1.39A 1fm6X-4hooA:
undetectable		 1fm6X-4hooA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 6 ASN A 153
TRP A  57
HIS A 205
TYR A 203
 None
 1.34A 1mxdA-4hooA:
undetectable		 1mxdA-4hooA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 7 ASN A 153
TRP A  57
HIS A 205
TYR A 203
 None
 1.35A 1mxgA-4hooA:
undetectable		 1mxgA-4hooA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		5 / 10 ALA A 290
TRP A 212
LEU A 204
GLY A 269
PHE A 271
 None
 1.45A 1ruaH-4hooA:
undetectable
1ruaL-4hooA:
undetectable		 1ruaH-4hooA:
18.32
1ruaL-4hooA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 5 PRO A 134
GLY A 286
ASN A 284
GLY A 183
 None
 1.05A 1zlqA-4hooA:
undetectable		 1zlqA-4hooA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		3 / 3 ASP A 120
ASN A 117
THR A 265
 None
 0.74A 2pymB-4hooA:
undetectable		 2pymB-4hooA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 7 ALA A  49
ILE A  20
ILE A  51
HIS A  22
 None
 1.12A 2zm7A-4hooA:
undetectable		 2zm7A-4hooA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 6 ARG A 243
SER A 308
GLY A 278
GLU A  39
 None
 0.94A 3k9fA-4hooA:
undetectable
3k9fB-4hooA:
undetectable
3k9fD-4hooA:
undetectable		 3k9fA-4hooA:
22.22
3k9fB-4hooA:
22.22
3k9fD-4hooA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		3 / 3 THR A 177
ASN A 176
GLU A 173
 None
 0.78A 3v4tA-4hooA:
undetectable
3v4tC-4hooA:
undetectable		 3v4tA-4hooA:
20.52
3v4tC-4hooA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		3 / 3 TYR A 279
ASP A 197
ASP A 195
 None
 0.84A 4a6eA-4hooA:
undetectable		 4a6eA-4hooA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 6 ALA A 296
GLY A 304
ILE A 160
VAL A 325
 None
 0.79A 4r21A-4hooA:
undetectable		 4r21A-4hooA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 5 GLU A  39
TYR A 199
PHE A 275
TYR A 303
 None
 1.46A 4twdA-4hooA:
undetectable
4twdE-4hooA:
undetectable		 4twdA-4hooA:
20.35
4twdE-4hooA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 5 TYR A 303
GLU A  39
TYR A 199
PHE A 275
 None
 1.48A 4twdA-4hooA:
undetectable
4twdB-4hooA:
undetectable		 4twdA-4hooA:
20.35
4twdB-4hooA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 5 TYR A 303
GLU A  39
TYR A 199
PHE A 275
 None
 1.43A 4twdC-4hooA:
undetectable
4twdD-4hooA:
undetectable		 4twdC-4hooA:
20.35
4twdD-4hooA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 5 TYR A 303
GLU A  39
TYR A 199
PHE A 275
 None
 1.46A 4twdH-4hooA:
0.0
4twdI-4hooA:
0.0		 4twdH-4hooA:
20.35
4twdI-4hooA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		3 / 3 MET A  96
GLU A 100
LEU A 104
 None
 0.77A 4v2oB-4hooA:
undetectable		 4v2oB-4hooA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 6 LEU A 154
ILE A 160
THR A 159
TRP A 300
 None
 1.41A 5ljeA-4hooA:
undetectable		 5ljeA-4hooA:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		6 / 6 GLU A 224
ARG A 228
ALA A 240
LEU A 242
TYR A 279
SER A 308
 None
 0.66A 5phhA-4hooA:
45.2		 5phhA-4hooA:
99.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		6 / 12 VAL A  98
PHE A 182
ILE A  71
ILE A 140
LEU A 180
HIS A 205
 None
 1.37A 5uvmB-4hooA:
undetectable		 5uvmB-4hooA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens) 		4 / 7 GLY A 220
GLN A 309
ASP A 197
TYR A 303
 None
 1.29A 5vlmG-4hooA:
undetectable		 5vlmG-4hooA:
20.00