SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 8 HIS A  55
LEU A  58
LEU A  81
SER A  51
 None
 1.04A 1i7zA-4houA:
undetectable		 1i7zA-4houA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		3 / 3 ASP A 189
HIS A 198
ASP A 229
 None
 0.88A 1nw5A-4houA:
undetectable		 1nw5A-4houA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 ALA A 160
SER A 184
TYR A  50
TYR A 256
TYR A 186
 None
 1.42A 1xvaB-4houA:
undetectable		 1xvaB-4houA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 7 ASN A  68
LEU A  75
MET A  32
MET A 104
 None
 1.17A 2w8yA-4houA:
undetectable		 2w8yA-4houA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 7 VAL A 221
ILE A 183
GLY A 180
LEU A 168
 None
 0.90A 3bjwF-4houA:
undetectable		 3bjwF-4houA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 7 VAL A 221
ILE A 183
GLY A 180
LEU A 168
 None
 0.90A 3bjwH-4houA:
undetectable		 3bjwH-4houA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 LEU A 168
PHE A  45
ILE A 219
ALA A 182
SER A 184
 None
 1.13A 3kk6A-4houA:
undetectable		 3kk6A-4houA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 ASN A 216
GLY A 180
ASN A 174
ASP A 142
CYH A 163
 None
 1.41A 3r24A-4houA:
undetectable		 3r24A-4houA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 ALA A 179
TYR A 256
ASN A 216
GLY A 180
ILE A 183
 None
 1.36A 3vwqA-4houA:
undetectable		 3vwqA-4houA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 6 LEU A  57
ASN A 100
LEU A  75
GLU A  77
 None
 1.22A 4nc3A-4houA:
undetectable		 4nc3A-4houA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 TRP A 147
ALA A 182
LEU A 206
GLY A 217
ILE A 183
 None
 1.09A 5m24A-4houA:
undetectable		 5m24A-4houA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 ALA A 102
ALA A 162
ALA A 160
LEU A  25
THR A  97
 None
 1.10A 5tl8A-4houA:
undetectable		 5tl8A-4houA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		3 / 3 GLU A 122
ARG A 133
TYR A 134
 None
 0.37A 5trqB-4houA:
undetectable		 5trqB-4houA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 7 LEU A  57
ASN A 100
VAL A  96
GLU A  77
 None
 0.99A 5tudA-4houA:
2.2		 5tudA-4houA:
20.61