SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		5 / 12 GLY A  47
GLY A  24
ASP A  23
ASP A  16
ASP A  46
 None
SO4  A 201 (-3.4A)
GOL  A 202 ( 2.6A)
None
None
 1.13A 3prsA-4hp4A:
undetectable		 3prsA-4hp4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		3 / 3 PHE A 110
CYH A 108
HIS A 129
 None
MLY  A 130 ( 3.9A)
None
 1.04A 3u9fF-4hp4A:
undetectable		 3u9fF-4hp4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		3 / 3 PHE A 110
CYH A 108
HIS A 129
 None
MLY  A 130 ( 3.9A)
None
 0.92A 3u9fG-4hp4A:
undetectable		 3u9fG-4hp4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		3 / 3 PHE A 110
CYH A 108
HIS A 129
 None
MLY  A 130 ( 3.9A)
None
 1.04A 3u9fL-4hp4A:
undetectable		 3u9fL-4hp4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		3 / 3 PHE A 110
CYH A 108
HIS A 129
 None
MLY  A 130 ( 3.9A)
None
 0.93A 3u9fS-4hp4A:
undetectable		 3u9fS-4hp4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		4 / 8 PHE A  22
SER A  45
ALA A 127
LEU A 126
 None
 1.04A 4rkuA-4hp4A:
undetectable
4rkuJ-4hp4A:
undetectable		 4rkuA-4hp4A:
10.65
4rkuJ-4hp4A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		4 / 7 PHE A  22
SER A  45
ALA A 127
LEU A 126
 None
 1.07A 4xk8A-4hp4A:
undetectable		 4xk8A-4hp4A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		5 / 12 PHE A  48
ASN A  28
PRO A 105
LEU A  69
PHE A 106
 None
None
None
None
MLY  A 100 ( 4.5A)
 1.17A 5xxiA-4hp4A:
undetectable		 5xxiA-4hp4A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4hp4 EAG-LIKE K[+]
CHANNEL
(Drosophila
melanogaster) 		5 / 12 LEU A  51
GLY A  47
LYS A  63
VAL A  42
CYH A  44
 None
None
MLY  A  62 ( 3.3A)
None
None
 1.43A 6bxnB-4hp4A:
undetectable		 6bxnB-4hp4A:
19.28