SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 8 LYS A 112
ALA A 113
SER A  74
THR A  76
 None
 0.97A 1dvtA-4hp8A:
undetectable
1dvtB-4hp8A:
undetectable		 1dvtA-4hp8A:
20.56
1dvtB-4hp8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 10 GLY A  22
ASN A  18
LEU A  29
VAL A  36
ALA A  87
 None
NAP  A 301 (-3.1A)
None
None
NAP  A 301 (-3.7A)
 1.24A 1fpqA-4hp8A:
6.1		 1fpqA-4hp8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 10 GLY A 158
HIS A 157
ALA A 138
THR A 163
ALA A 181
 None
 1.43A 1gtnO-4hp8A:
undetectable
1gtnP-4hp8A:
undetectable		 1gtnO-4hp8A:
15.26
1gtnP-4hp8A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 9 GLY A 158
HIS A 157
ALA A 138
THR A 163
ALA A 181
 None
 1.39A 1gtnQ-4hp8A:
undetectable
1gtnR-4hp8A:
undetectable		 1gtnQ-4hp8A:
15.26
1gtnR-4hp8A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 181
GLY A 183
ILE A 137
ALA A 179
SER A 142
 None
None
NAP  A 301 (-4.5A)
None
None
 1.03A 1ve3B-4hp8A:
6.9		 1ve3B-4hp8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  16
ARG A  41
ASP A  64
ASN A  86
ALA A  87
 NAP  A 301 (-3.1A)
NAP  A 301 (-3.3A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.2A)
NAP  A 301 (-3.7A)
 0.96A 2bm9E-4hp8A:
5.3		 2bm9E-4hp8A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 218
GLY A  20
ILE A 137
VAL A  84
VAL A  27
 None
NAP  A 301 (-3.3A)
NAP  A 301 (-4.5A)
None
None
 1.01A 2qe6B-4hp8A:
4.9		 2qe6B-4hp8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 218
GLY A  22
GLY A  20
ILE A 137
VAL A  27
 None
None
NAP  A 301 (-3.3A)
NAP  A 301 (-4.5A)
None
 1.07A 2qe6B-4hp8A:
4.9		 2qe6B-4hp8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 9 ILE A 203
ASP A 241
LEU A 140
GLY A 183
THR A 153
 None
 1.30A 2tsrD-4hp8A:
undetectable		 2tsrD-4hp8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 TYR A 152
ILE A 185
GLY A 183
ILE A 207
GLY A 213
 NAP  A 301 (-4.5A)
NAP  A 301 (-4.3A)
None
None
None
 1.03A 3bwcA-4hp8A:
5.7		 3bwcA-4hp8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 6 ILE A  50
ILE A 137
GLY A  22
VAL A 223
 None
NAP  A 301 (-4.5A)
None
None
 0.91A 3n3iA-4hp8A:
undetectable		 3n3iA-4hp8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 203
ASP A 241
LEU A 140
GLY A 183
THR A 153
 None
 1.22A 5x5qB-4hp8A:
undetectable		 5x5qB-4hp8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 203
ASP A 241
GLY A 183
THR A 153
ALA A 246
 None
 0.90A 5x66F-4hp8A:
undetectable		 5x66F-4hp8A:
22.26