SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hpe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.10A 1c8lA-4hpeA:
undetectable		 1c8lA-4hpeA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.08A 1gfzA-4hpeA:
undetectable		 1gfzA-4hpeA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.09A 1l5qA-4hpeA:
undetectable		 1l5qA-4hpeA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.11A 1l5qB-4hpeA:
undetectable		 1l5qB-4hpeA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.13A 1l7xB-4hpeA:
undetectable		 1l7xB-4hpeA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		5 / 12 ALA A 267
LEU A 281
SER A 256
ILE A 255
LEU A 213
 CL  A 403 ( 4.4A)
None
None
None
None
 1.06A 1rg7A-4hpeA:
undetectable		 1rg7A-4hpeA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 5 LYS A  60
PHE A 116
MET A  90
LEU A  47
 None
 1.48A 1skxA-4hpeA:
undetectable		 1skxA-4hpeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		5 / 11 VAL A  51
GLY A  84
ILE A 109
LYS A  53
THR A 105
 None
 1.32A 3bf1A-4hpeA:
undetectable
3bf1B-4hpeA:
undetectable		 3bf1A-4hpeA:
22.43
3bf1B-4hpeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		5 / 11 LYS A  53
THR A 105
VAL A  51
GLY A  84
ILE A 109
 None
 1.31A 3bf1E-4hpeA:
undetectable
3bf1F-4hpeA:
undetectable		 3bf1E-4hpeA:
22.43
3bf1F-4hpeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.08A 3dd1A-4hpeA:
undetectable		 3dd1A-4hpeA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.08A 3dd1B-4hpeA:
undetectable		 3dd1B-4hpeA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.06A 3ddsA-4hpeA:
undetectable		 3ddsA-4hpeA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.08A 3ddsB-4hpeA:
undetectable		 3ddsB-4hpeA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.08A 3ddwA-4hpeA:
undetectable		 3ddwA-4hpeA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 ASN A 139
HIS A 155
GLY A 141
TYR A 144
 GOL  A 406 ( 3.9A)
None
None
None
 1.09A 3ddwB-4hpeA:
undetectable		 3ddwB-4hpeA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 7 GLU A  81
SER A  82
VAL A  80
VAL A  51
 GOL  A 406 (-2.9A)
None
None
None
 1.28A 3n61A-4hpeA:
undetectable
3n61B-4hpeA:
undetectable		 3n61A-4hpeA:
21.16
3n61B-4hpeA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 LEU A 281
ALA A 221
LEU A 245
THR A 246
 None
None
OCS  A 242 ( 4.4A)
OCS  A 242 ( 3.4A)
 1.12A 3rozA-4hpeA:
undetectable		 3rozA-4hpeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 8 GLY A 141
TYR A 147
SER A 137
TYR A 140
 None
 0.70A 3u9hA-4hpeA:
undetectable		 3u9hA-4hpeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 8 GLY A 141
TYR A 147
SER A 137
TYR A 140
 None
 0.73A 3u9hB-4hpeA:
undetectable		 3u9hB-4hpeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 7 TYR A 229
ASP A 241
SER A 243
HIS A 296
 OCS  A 242 ( 4.7A)
OCS  A 242 ( 4.1A)
OCS  A 242 ( 3.6A)
OCS  A 242 ( 3.7A)
 1.26A 4arcA-4hpeA:
undetectable		 4arcA-4hpeA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 8 GLY A 141
TYR A 147
SER A 137
TYR A 140
 None
 0.67A 4bjcA-4hpeA:
undetectable		 4bjcA-4hpeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 7 GLY A 141
TYR A 147
SER A 137
TYR A 140
 None
 0.86A 4hyfA-4hpeA:
undetectable		 4hyfA-4hpeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 8 GLY A 141
TYR A 147
SER A 137
TYR A 140
 None
 0.88A 4hyfB-4hpeA:
undetectable		 4hyfB-4hpeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 8 GLY A 141
TYR A 147
SER A 137
TYR A 140
 None
 0.83A 4hyfC-4hpeA:
undetectable		 4hyfC-4hpeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		3 / 3 TYR A 175
GLN A 136
TRP A 189
 None
 1.16A 4kn2C-4hpeA:
undetectable		 4kn2C-4hpeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 5 TYR A 196
TYR A 175
GLU A  81
ASP A  88
 GOL  A 406 ( 4.5A)
None
GOL  A 406 (-2.9A)
None
 1.27A 4x61A-4hpeA:
undetectable		 4x61A-4hpeA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7
(Clostridioides
difficile) 		4 / 6 TYR A 196
TYR A 175
GLU A  81
ASP A  88
 GOL  A 406 ( 4.5A)
None
GOL  A 406 (-2.9A)
None
 1.28A 5emlA-4hpeA:
undetectable		 5emlA-4hpeA:
17.67