SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hpf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		3 / 3 MET A 431
LEU A 434
SER A 435
 None
 0.64A 1ee2A-4hpfA:
4.9		 1ee2A-4hpfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 8 PHE A 482
GLY A 486
VAL A1017
PHE A 901
 None
 1.15A 1gsfA-4hpfA:
undetectable		 1gsfA-4hpfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 8 PHE A 482
GLY A 486
VAL A1017
PHE A 901
 None
 1.15A 1gsfB-4hpfA:
undetectable		 1gsfB-4hpfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 8 PHE A 482
GLY A 486
VAL A1017
PHE A 901
 None
 1.15A 1gsfD-4hpfA:
undetectable		 1gsfD-4hpfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 GLY A 491
SER A 795
ILE A 716
LEU A 488
GLY A 486
 None
 0.88A 1uakA-4hpfA:
undetectable		 1uakA-4hpfA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 GLN A 448
ASP A 426
GLY A 730
LEU A 731
SER A 422
 None
 1.33A 2nv4A-4hpfA:
undetectable		 2nv4A-4hpfA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 6 ALA A 424
ASP A 421
GLU A 425
ARG A 432
 None
 1.45A 2ouzA-4hpfA:
undetectable		 2ouzA-4hpfA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 776
GLY A 784
ILE A 824
VAL A 752
ILE A 754
 None
 1.01A 2pynB-4hpfA:
undetectable		 2pynB-4hpfA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 776
GLY A 784
ILE A 824
VAL A 752
ILE A 754
 None
 0.98A 2q63B-4hpfA:
undetectable		 2q63B-4hpfA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 776
GLY A 784
ILE A 824
VAL A 752
ILE A 754
 None
 0.94A 2qakB-4hpfA:
undetectable		 2qakB-4hpfA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 966
ILE A 995
ARG A 979
GLY A 988
 None
 0.86A 3b9lA-4hpfA:
undetectable		 3b9lA-4hpfA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 776
GLY A 784
ILE A 824
VAL A 752
ILE A 754
 None
 0.96A 3cyxA-4hpfA:
undetectable		 3cyxA-4hpfA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 589
GLY A 999
PHE A1034
LEU A 492
LEU A 572
 None
 1.06A 3em0B-4hpfA:
undetectable		 3em0B-4hpfA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		3 / 3 ARG A 960
ASP A 681
GLN A 772
 None
 0.95A 3lcvB-4hpfA:
4.1		 3lcvB-4hpfA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 9 ILE A 447
ILE A 449
VAL A 433
TYR A 457
ILE A 427
 None
 1.39A 3p4wA-4hpfA:
undetectable		 3p4wA-4hpfA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 6 PHE A 517
PHE A 895
ALA A 894
THR A 899
 None
 1.16A 3t3sB-4hpfA:
undetectable		 3t3sB-4hpfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 7 PHE A 517
PHE A 895
ALA A 894
THR A 899
 None
 1.09A 3t3sC-4hpfA:
undetectable		 3t3sC-4hpfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 7 PRO A1021
HIS A 551
GLY A 983
PHE A 982
 None
 0.99A 3tehB-4hpfA:
undetectable		 3tehB-4hpfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 776
GLY A 784
ILE A 824
VAL A 752
ILE A 754
 None
 0.99A 3tkgB-4hpfA:
undetectable		 3tkgB-4hpfA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 11 TRP A 464
ILE A 446
ILE A 473
LEU A 478
VAL A 927
 None
 1.11A 3w67A-4hpfA:
undetectable		 3w67A-4hpfA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 9 LEU A 367
ILE A 472
LEU A 458
ILE A 430
MET A 395
 None
 1.16A 3zosB-4hpfA:
undetectable		 3zosB-4hpfA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 8 TYR A 917
ILE A 472
ASN A 471
GLU A 558
 None
 1.03A 4a97D-4hpfA:
undetectable		 4a97D-4hpfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 7 TYR A 917
ILE A 472
ASN A 471
GLU A 558
 None
 0.92A 4a97H-4hpfA:
undetectable		 4a97H-4hpfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 8 TYR A 917
ILE A 472
ASN A 471
GLU A 558
 None
 1.09A 4a97I-4hpfA:
undetectable		 4a97I-4hpfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 6 THR A 823
GLY A 825
ILE A 861
LEU A 877
 None
 1.24A 4acaC-4hpfA:
5.9		 4acaC-4hpfA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 TYR A 915
ASN A 471
ARG A 444
LEU A 412
ILE A 334
 None
 1.32A 4k36A-4hpfA:
undetectable		 4k36A-4hpfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		3 / 3 TRP A 768
GLN A 772
THR A 695
 None
 1.01A 4m2xA-4hpfA:
undetectable		 4m2xA-4hpfA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 754
GLY A 755
CYH A 779
ALA A 780
LEU A 786
 None
 0.82A 5hw4A-4hpfA:
undetectable		 5hw4A-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 754
GLY A 778
CYH A 779
ALA A 780
VAL A 799
 None
 1.25A 5hw4A-4hpfA:
undetectable		 5hw4A-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 11 ILE A 754
GLY A 755
CYH A 779
ALA A 780
LEU A 786
 None
 0.79A 5hw4B-4hpfA:
undetectable		 5hw4B-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 11 ILE A 754
GLY A 778
CYH A 779
ALA A 780
VAL A 799
 None
 1.23A 5hw4B-4hpfA:
undetectable		 5hw4B-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 754
GLY A 755
CYH A 779
ALA A 780
LEU A 786
 None
 0.80A 5hw4C-4hpfA:
2.2		 5hw4C-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 754
GLY A 778
CYH A 779
ALA A 780
VAL A 799
 None
 1.22A 5hw4C-4hpfA:
2.2		 5hw4C-4hpfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 9 ILE A 447
ILE A 449
VAL A 433
TYR A 457
ILE A 427
 None
 1.30A 5mvnB-4hpfA:
undetectable		 5mvnB-4hpfA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 10 ILE A 447
ILE A 449
VAL A 433
TYR A 457
ILE A 427
 None
 1.29A 5mvnD-4hpfA:
undetectable		 5mvnD-4hpfA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 12 GLY A 491
SER A 795
ILE A 716
LEU A 488
GLY A 486
 None
 0.88A 5wyqB-4hpfA:
undetectable		 5wyqB-4hpfA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		4 / 4 PHE A 734
LEU A 492
LEU A 862
VAL A 927
 None
 1.13A 5xxiA-4hpfA:
undetectable		 5xxiA-4hpfA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 11 GLY A 755
ASP A 785
TYR A 782
CYH A 797
ILE A 824
 None
 1.49A 6agoA-4hpfA:
undetectable		 6agoA-4hpfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens) 		5 / 10 GLY A 825
LEU A 822
THR A 863
VAL A 799
ALA A 817
 None
 1.15A 6czmA-4hpfA:
2.3
6czmC-4hpfA:
undetectable		 6czmA-4hpfA:
19.10
6czmC-4hpfA:
19.10