SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FE2_A_LAXA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	4hpk	COLLAGENASE (Hathewaya histolytica)	5 / 10	VAL A1006 PHE A 952 VAL A 954 VAL A 993 LEU A1004	None	1.22A	1fe2A-4hpkA: undetectable	1fe2A-4hpkA: 10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L2U_A_ELVA397_1 (INTEGRASE)	4hpk	COLLAGENASE (Hathewaya histolytica)	4 / 5	ASP A 927 ASP A 904 TYR A 931 GLU A 901	CA A1101 ( 2.8A) CA A1101 (-3.2A) None CA A1101 ( 2.2A)	1.28A	3l2uA-4hpkA: undetectable	3l2uA-4hpkA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L2V_A_RLTA397_1 (INTEGRASE)	4hpk	COLLAGENASE (Hathewaya histolytica)	4 / 7	ASP A 927 ASP A 904 TYR A 931 GLU A 901	CA A1101 ( 2.8A) CA A1101 (-3.2A) None CA A1101 ( 2.2A)	1.26A	3l2vA-4hpkA: undetectable	3l2vA-4hpkA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L2W_A_ELVA397_1 (INTEGRASE)	4hpk	COLLAGENASE (Hathewaya histolytica)	4 / 5	ASP A 927 ASP A 904 TYR A 931 GLU A 901	CA A1101 ( 2.8A) CA A1101 (-3.2A) None CA A1101 ( 2.2A)	1.27A	3l2wA-4hpkA: undetectable	3l2wA-4hpkA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3O_A_DLUA399_1 (PFV INTEGRASE)	4hpk	COLLAGENASE (Hathewaya histolytica)	4 / 7	ASP A 927 ASP A 904 TYR A 931 GLU A 901	CA A1101 ( 2.8A) CA A1101 (-3.2A) None CA A1101 ( 2.2A)	1.21A	3s3oA-4hpkA: undetectable	3s3oA-4hpkA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G2P_A_TRPA502_0 (FLAVIN-DEPENDENT L-TRYPTOPHAN OXIDASE VIOA)	4hpk	COLLAGENASE (Hathewaya histolytica)	4 / 7	TYR A 994 LEU A 946 TYR A 996 VAL A 978	None	1.24A	6g2pA-4hpkA: undetectable	6g2pA-4hpkA: 13.57

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FE2_A_LAXA700_1","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","4hpk","COLLAGENASE","Hathewaya histolytica",5,"VAL A1006;PHE A 952;VAL A 954;VAL A 993;LEU A1004","None","1.22A","1fe2A-4hpkA:undetectable","1fe2A-4hpkA:10.86"],["3L2U_A_ELVA397_1","INTEGRASE","4hpk","COLLAGENASE","Hathewaya histolytica",4,"ASP A 927;ASP A 904;TYR A 931;GLU A 901"," CA A1101 ( 2.8A); CA A1101 (-3.2A);None; CA A1101 ( 2.2A)","1.28A","3l2uA-4hpkA:undetectable","3l2uA-4hpkA:13.58"],["3L2V_A_RLTA397_1","INTEGRASE","4hpk","COLLAGENASE","Hathewaya histolytica",4,"ASP A 927;ASP A 904;TYR A 931;GLU A 901"," CA A1101 ( 2.8A); CA A1101 (-3.2A);None; CA A1101 ( 2.2A)","1.26A","3l2vA-4hpkA:undetectable","3l2vA-4hpkA:13.58"],["3L2W_A_ELVA397_1","INTEGRASE","4hpk","COLLAGENASE","Hathewaya histolytica",4,"ASP A 927;ASP A 904;TYR A 931;GLU A 901"," CA A1101 ( 2.8A); CA A1101 (-3.2A);None; CA A1101 ( 2.2A)","1.27A","3l2wA-4hpkA:undetectable","3l2wA-4hpkA:13.58"],["3S3O_A_DLUA399_1","PFV INTEGRASE","4hpk","COLLAGENASE","Hathewaya histolytica",4,"ASP A 927;ASP A 904;TYR A 931;GLU A 901"," CA A1101 ( 2.8A); CA A1101 (-3.2A);None; CA A1101 ( 2.2A)","1.21A","3s3oA-4hpkA:undetectable","3s3oA-4hpkA:13.58"],["6G2P_A_TRPA502_0","FLAVIN-DEPENDENT L-TRYPTOPHAN OXIDASE VIOA","4hpk","COLLAGENASE","Hathewaya histolytica",4,"TYR A 994;LEU A 946;TYR A 996;VAL A 978","None","1.24A","6g2pA-4hpkA:undetectable","6g2pA-4hpkA:13.57"]]