SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 423
THR A  49
HIS A 422
HIS A 438
 None
 1.37A 1d4fA-4hppA:
undetectable		 1d4fA-4hppA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 5 THR A 281
THR A 340
THR A 232
HIS A 236
 None
None
GLU  A 503 (-4.2A)
GLU  A 503 (-4.1A)
 1.23A 1d4fB-4hppA:
undetectable		 1d4fB-4hppA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 159
GLY A 157
ARG A 154
PHE A 177
 None
 1.00A 1gsfA-4hppA:
undetectable		 1gsfA-4hppA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 159
GLY A 157
ARG A 154
PHE A 177
 None
 1.00A 1gsfB-4hppA:
undetectable		 1gsfB-4hppA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 159
GLY A 157
ARG A 154
PHE A 177
 None
 1.00A 1gsfC-4hppA:
undetectable		 1gsfC-4hppA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 159
GLY A 157
ARG A 154
PHE A 177
 None
 1.00A 1gsfD-4hppA:
undetectable		 1gsfD-4hppA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 345
ALA A 348
LEU A 404
LEU A 277
ALA A 276
 None
 0.80A 2bxeA-4hppA:
undetectable		 2bxeA-4hppA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 345
ALA A 348
LEU A 404
LEU A 277
ALA A 276
 None
 0.79A 2bxgB-4hppA:
undetectable		 2bxgB-4hppA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A  15
ALA A 170
ASN A 204
LEU A  89
 None
 1.04A 2hzqA-4hppA:
undetectable		 2hzqA-4hppA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 139
PRO A 140
ARG A 154
 None
 0.35A 2qd4B-4hppA:
undetectable		 2qd4B-4hppA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 10 HIS A 438
ALA A 223
GLU A 441
ALA A 440
TYR A 439
 None
 1.41A 2r2vC-4hppA:
undetectable
2r2vF-4hppA:
undetectable
2r2vG-4hppA:
undetectable		 2r2vC-4hppA:
6.96
2r2vF-4hppA:
6.96
2r2vG-4hppA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 392
LEU A 417
CYH A 405
LEU A 280
CYH A 278
 None
 1.18A 3cldA-4hppA:
undetectable		 3cldA-4hppA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 163
ALA A 156
GLY A 138
LEU A 137
VAL A 212
 None
 0.98A 3em6B-4hppA:
undetectable		 3em6B-4hppA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 134
PHE A 222
ALA A 213
LEU A 139
 None
 0.90A 4ejgC-4hppA:
undetectable		 4ejgC-4hppA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 279
GLU A 423
LEU A 391
LEU A 395
 None
 1.02A 4iomA-4hppA:
undetectable		 4iomA-4hppA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  96
GLU A  98
LEU A 412
HIS A 343
 None
 1.35A 4xi3B-4hppA:
undetectable		 4xi3B-4hppA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 202
HIS A  93
ASN A 204
ARG A 206
 None
 1.27A 5db5A-4hppA:
undetectable
5db5B-4hppA:
undetectable		 5db5A-4hppA:
22.90
5db5B-4hppA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A 273
LEU A 277
CYH A 405
LEU A 398
 None
 1.39A 5hrqD-4hppA:
undetectable
5hrqG-4hppA:
undetectable
5hrqH-4hppA:
undetectable		 5hrqD-4hppA:
5.80
5hrqG-4hppA:
3.82
5hrqH-4hppA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 339
GLN A  51
MET A 419
THR A 427
 None
 1.17A 5u6mA-4hppA:
undetectable		 5u6mA-4hppA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 339
GLN A  51
MET A 419
THR A 427
 None
 1.16A 5u6mB-4hppA:
undetectable		 5u6mB-4hppA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4hpp PROBABLE GLUTAMINE
SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  15
VAL A  13
SER A  11
VAL A 205
ASN A 204
 None
 1.43A 6h7lB-4hppA:
undetectable		 6h7lB-4hppA:
13.55