SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hpv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 197
GLY A 275
LEU A  27
MET A 217
VAL A 237
 None
 1.05A 1i9gA-4hpvA:
undetectable		 1i9gA-4hpvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 VAL A 107
ILE A 110
GLU A  39
LEU A 397
 None
 1.05A 1j96B-4hpvA:
undetectable		 1j96B-4hpvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.85A 1p7lC-4hpvA:
27.4		 1p7lC-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.33A 1p7lD-4hpvA:
27.2		 1p7lD-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.88A 1p7lD-4hpvA:
27.2		 1p7lD-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.83A 1rg9A-4hpvA:
27.5		 1rg9A-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.83A 1rg9B-4hpvA:
27.4		 1rg9B-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.37A 1rg9C-4hpvA:
27.4		 1rg9C-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.90A 1rg9C-4hpvA:
27.4		 1rg9C-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.36A 1rg9D-4hpvA:
27.4		 1rg9D-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.87A 1rg9D-4hpvA:
27.4		 1rg9D-4hpvA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLU A 279
GLY A 275
TYR A 125
ARG A 124
ALA A 218
 None
 1.02A 2bm9A-4hpvA:
undetectable		 2bm9A-4hpvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLU A 279
GLY A 275
TYR A 125
ARG A 124
ALA A 218
 None
 0.95A 2br4A-4hpvA:
undetectable		 2br4A-4hpvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLU A 279
GLY A 275
TYR A 125
ARG A 124
ALA A 218
 None
 0.95A 2br4E-4hpvA:
undetectable		 2br4E-4hpvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 PHE A 123
ARG A 124
GLY A  28
THR A 276
 None
 1.10A 2f7fA-4hpvA:
undetectable		 2f7fA-4hpvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 ASN A 311
HIS A  59
ASN A 314
ILE A 349
 None
 1.16A 2hkkA-4hpvA:
undetectable		 2hkkA-4hpvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 TRP A 118
ALA A 308
VAL A  37
 None
 0.82A 2izqA-4hpvA:
undetectable
2izqB-4hpvA:
undetectable		 2izqA-4hpvA:
4.56
2izqB-4hpvA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.89A 2obvA-4hpvA:
27.7		 2obvA-4hpvA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.86A 2p02A-4hpvA:
27.7		 2p02A-4hpvA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 ASN A 209
ARG A 206
ASP A  13
 None
 0.82A 2qe6A-4hpvA:
undetectable		 2qe6A-4hpvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 ASN A 209
ARG A 206
ASP A  13
 None
 0.82A 2qe6B-4hpvA:
undetectable		 2qe6B-4hpvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 HIS A  59
ALA A  41
ALA A  38
THR A 286
 None
 0.95A 2xfhA-4hpvA:
undetectable		 2xfhA-4hpvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLU A 181
PHE A 123
GLY A  28
GLY A 197
GLY A  26
 None
 1.12A 3tegA-4hpvA:
2.4		 3tegA-4hpvA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 THR A 297
PRO A 301
GLY A 166
PHE A 167
 None
 1.02A 3tzfB-4hpvA:
undetectable		 3tzfB-4hpvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A 123
ILE A  80
ILE A  84
VAL A  66
VAL A  37
 None
 0.97A 3w68D-4hpvA:
undetectable		 3w68D-4hpvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 5 GLY A 139
THR A  94
ILE A 111
VAL A 107
 None
 0.82A 3wriA-4hpvA:
undetectable		 3wriA-4hpvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 5 GLY A 139
THR A  94
ILE A 111
VAL A 107
 None
 0.81A 3wriB-4hpvA:
undetectable		 3wriB-4hpvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.97A 4e3aA-4hpvA:
undetectable		 4e3aA-4hpvA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 ASN A  60
ASN A 159
ASP A 160
ILE A 349
 None
 0.77A 4k0bA-4hpvA:
63.5		 4k0bA-4hpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		7 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ALA A 216
TYR A 270
SER A 277
 None
 0.20A 4k0bB-4hpvA:
62.0		 4k0bB-4hpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		7 / 8 PRO A  30
ASP A 199
LYS A 201
ALA A 216
TYR A 270
SER A 277
ASP A 282
 None
 0.85A 4k0bB-4hpvA:
62.0		 4k0bB-4hpvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.97A 4k8pA-4hpvA:
undetectable		 4k8pA-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.96A 4k8pB-4hpvA:
undetectable		 4k8pB-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.97A 4k8tA-4hpvA:
undetectable		 4k8tA-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.98A 4k8tB-4hpvA:
undetectable		 4k8tB-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.98A 4k93A-4hpvA:
undetectable		 4k93A-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.97A 4k93B-4hpvA:
undetectable		 4k93B-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.98A 4k9cA-4hpvA:
undetectable		 4k9cA-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.96A 4k9cB-4hpvA:
undetectable		 4k9cB-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.86A 4kttA-4hpvA:
25.2		 4kttA-4hpvA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.85A 4kttC-4hpvA:
25.2		 4kttC-4hpvA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.91A 4ktvA-4hpvA:
25.4
4ktvB-4hpvA:
27.5		 4ktvA-4hpvA:
24.95
4ktvB-4hpvA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 11 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.88A 4ktvC-4hpvA:
25.2
4ktvD-4hpvA:
27.4		 4ktvC-4hpvA:
24.95
4ktvD-4hpvA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A 323
VAL A 345
ASP A 383
ILE A   4
 None
 0.93A 4l4cB-4hpvA:
undetectable		 4l4cB-4hpvA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 ASN A  60
ASN A 159
ASP A 160
ILE A 349
 None
 0.81A 4l7iA-4hpvA:
63.6		 4l7iA-4hpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		7 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ALA A 216
TYR A 270
SER A 277
 None
 0.22A 4l7iB-4hpvA:
61.9		 4l7iB-4hpvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		7 / 8 PRO A  30
ASP A 199
LYS A 201
ALA A 216
TYR A 270
SER A 277
ASP A 282
 None
 0.83A 4l7iB-4hpvA:
61.9		 4l7iB-4hpvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 281
GLY A  68
SER A 277
THR A 276
LEU A 126
 None
 0.97A 4lbxA-4hpvA:
undetectable		 4lbxA-4hpvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.90A 4ndnA-4hpvA:
2.9		 4ndnA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 7 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.84A 4ndnC-4hpvA:
25.3		 4ndnC-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.30A 4odjA-4hpvA:
27.8		 4odjA-4hpvA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.89A 4odjA-4hpvA:
27.8		 4odjA-4hpvA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 ASP A 199
ALA A 278
THR A 272
THR A 274
 None
 1.42A 4w5qA-4hpvA:
undetectable		 4w5qA-4hpvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 ASP A 199
ALA A 278
THR A 272
THR A 274
 None
 1.43A 4w5tA-4hpvA:
undetectable		 4w5tA-4hpvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 ASP A 199
ALA A 278
THR A 272
THR A 274
 None
 1.41A 4z4cA-4hpvA:
undetectable		 4z4cA-4hpvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 ASP A 199
ALA A 278
THR A 272
THR A 274
 None
 1.39A 4z4fA-4hpvA:
undetectable		 4z4fA-4hpvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 5 ASP A 199
ALA A 278
THR A 272
THR A 274
 None
 1.40A 4z4gA-4hpvA:
undetectable		 4z4gA-4hpvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 ASP A 199
ALA A 278
THR A 272
THR A 274
 None
 1.40A 4z4iA-4hpvA:
undetectable		 4z4iA-4hpvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.37A 5a1iA-4hpvA:
27.8		 5a1iA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.96A 5a1iA-4hpvA:
27.8		 5a1iA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.37A 5a1iA-4hpvA:
27.8		 5a1iA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.96A 5a1iA-4hpvA:
27.8		 5a1iA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 5 ILE A   4
LYS A 330
ILE A 331
VAL A 343
 None
 0.91A 5jmnA-4hpvA:
3.0		 5jmnA-4hpvA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.38A 5t8sB-4hpvA:
27.7		 5t8sB-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.96A 5t8sB-4hpvA:
27.7		 5t8sB-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 LEU A 323
VAL A 382
ASP A 383
 None
 0.65A 5x23A-4hpvA:
undetectable		 5x23A-4hpvA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 GLU A  23
ARG A 291
THR A 297
PRO A 298
 None
 1.32A 6a4iB-4hpvA:
undetectable		 6a4iB-4hpvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.84A 6fbnB-4hpvA:
25.1		 6fbnB-4hpvA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.34A 6fboA-4hpvA:
27.8		 6fboA-4hpvA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.98A 6fboA-4hpvA:
27.8		 6fboA-4hpvA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		5 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.89A 6fcbA-4hpvA:
27.9		 6fcbA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.34A 6fcdA-4hpvA:
27.6		 6fcdA-4hpvA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.96A 6fcdA-4hpvA:
27.6		 6fcdA-4hpvA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 HIS A  29
PRO A  30
ASP A 199
LYS A 201
 None
 0.38A 6g6rA-4hpvA:
27.7		 6g6rA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.98A 6g6rA-4hpvA:
27.7		 6g6rA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4hpv S-ADENOSYLMETHIONINE
SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 ILE A 119
GLU A 279
HIS A 131
VAL A 132
 None
 0.85A 6j20A-4hpvA:
undetectable		 6j20A-4hpvA:
19.66