SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4hpz DTALE2
(Xanthomonas) 		4 / 5 VAL A 397
SER A 367
VAL A 363
SER A 401
 None
 1.19A 2j9cA-4hpzA:
undetectable
2j9cB-4hpzA:
undetectable
2j9cC-4hpzA:
undetectable		 2j9cA-4hpzA:
14.00
2j9cB-4hpzA:
14.00
2j9cC-4hpzA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4hpz DTALE2
(Xanthomonas) 		4 / 7 GLY A 371
GLY A 370
VAL A 344
SER A 367
 None
 0.82A 2oa1B-4hpzA:
undetectable		 2oa1B-4hpzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4hpz DTALE2
(Xanthomonas) 		4 / 7 GLY A 507
GLY A 506
VAL A 480
SER A 503
 None
 0.80A 2oa1B-4hpzA:
undetectable		 2oa1B-4hpzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4hpz DTALE2
(Xanthomonas) 		5 / 12 ILE A 263
GLY A 267
GLY A 303
LEU A 307
HIS A 275
 None
 1.15A 2y7kD-4hpzA:
undetectable		 2y7kD-4hpzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4hpz DTALE2
(Xanthomonas) 		4 / 4 ARG A 380
ASP A 369
GLY A 336
THR A 343
 None
 1.46A 3k4vB-4hpzA:
undetectable		 3k4vB-4hpzA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 4hpz DTALE2
(Xanthomonas) 		5 / 11 PHE A 188
GLY A 187
GLY A 204
GLU A 239
MET A 213
 None
 1.43A 4a6nB-4hpzA:
undetectable		 4a6nB-4hpzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4hpz DTALE2
(Xanthomonas) 		4 / 5 LYS A 372
LEU A 375
GLU A 376
LEU A 347
 None
 1.24A 4k4yA-4hpzA:
undetectable		 4k4yA-4hpzA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4hpz DTALE2
(Xanthomonas) 		4 / 4 LYS A 372
LEU A 375
GLU A 376
LEU A 347
 None
 1.25A 4k4yE-4hpzA:
undetectable		 4k4yE-4hpzA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4hpz DTALE2
(Xanthomonas) 		4 / 5 LYS A 372
LEU A 375
GLU A 376
LEU A 347
 None
 1.26A 4k4yI-4hpzA:
undetectable		 4k4yI-4hpzA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4hpz DTALE2
(Xanthomonas) 		5 / 9 ALA A 240
GLY A 229
ILE A 225
ILE A 263
VAL A 272
 None
 1.12A 4nptA-4hpzA:
undetectable		 4nptA-4hpzA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hpz DTALE2
(Xanthomonas) 		5 / 12 THR A 283
ASP A 292
LEU A 255
LEU A 253
HIS A 275
 None
 1.30A 4pfjB-4hpzA:
undetectable		 4pfjB-4hpzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4hpz DTALE2
(Xanthomonas) 		5 / 9 GLY A 356
HIS A 355
VAL A 397
VAL A 378
LEU A 375
 None
 1.21A 4qd3A-4hpzA:
undetectable		 4qd3A-4hpzA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4hpz DTALE2
(Xanthomonas) 		5 / 9 GLY A 390
HIS A 389
VAL A 431
VAL A 412
LEU A 409
 None
 1.18A 4qd3A-4hpzA:
undetectable		 4qd3A-4hpzA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4hpz DTALE2
(Xanthomonas) 		5 / 9 SER A 469
ALA A 502
SER A 503
ALA A 476
GLY A 472
 None
 1.22A 6bklA-4hpzA:
undetectable
6bklB-4hpzA:
undetectable
6bklC-4hpzA:
undetectable
6bklD-4hpzA:
undetectable		 6bklA-4hpzA:
5.12
6bklB-4hpzA:
5.12
6bklC-4hpzA:
5.12
6bklD-4hpzA:
5.12