SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.21A 1hrkA-4hq1A:
undetectable
1hrkA-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.23A 1hrkB-4hq1A:
undetectable
1hrkB-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A 191
LEU A 216
ASN A 217
VAL A 172
ALA A 170
None
1.14A 1sa1A-4hq1A:
undetectable
1sa1B-4hq1A:
undetectable
1sa1A-4hq1A:
20.23
1sa1B-4hq1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 7 ILE A 225
LEU A 239
MET A 231
THR A 232
LEU A 234
None
1.48A 1v55A-4hq1A:
undetectable
1v55J-4hq1A:
undetectable
1v55A-4hq1A:
22.32
1v55J-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 6 ILE A 225
MET A 231
THR A 232
LEU A 234
None
0.98A 2einN-4hq1A:
undetectable
2einW-4hq1A:
undetectable
2einN-4hq1A:
22.32
2einW-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.17A 2hrcA-4hq1A:
undetectable
2hrcA-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.21A 2hrcB-4hq1A:
undetectable
2hrcB-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.21A 2pnjB-4hq1A:
undetectable
2pnjB-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.21A 2po5A-4hq1A:
undetectable
2po5A-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 11 LEU A 180
SER A 155
VAL A 130
VAL A 172
TRP A 150
None
1.38A 2po5B-4hq1A:
undetectable
2po5B-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.20A 2po7A-4hq1A:
undetectable
2po7A-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.20A 2po7B-4hq1A:
undetectable
2po7B-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 10 LEU A 248
LEU A 260
VAL A 284
SER A 274
PHE A 298
None
1.12A 2w9hA-4hq1A:
undetectable
2w9hA-4hq1A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 5 PHE A 244
PHE A 267
LEU A 248
PHE A 251
None
1.38A 3abmC-4hq1A:
undetectable
3abmJ-4hq1A:
undetectable
3abmC-4hq1A:
20.17
3abmJ-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 5 PHE A 244
PHE A 267
LEU A 248
PHE A 251
None
1.36A 3abmP-4hq1A:
undetectable
3abmW-4hq1A:
undetectable
3abmP-4hq1A:
20.17
3abmW-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 6 ILE A 225
MET A 231
THR A 232
LEU A 234
None
1.02A 3ag1N-4hq1A:
undetectable
3ag1W-4hq1A:
undetectable
3ag1N-4hq1A:
22.32
3ag1W-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 7 ILE A  71
LEU A  95
THR A  67
LEU A  90
None
0.96A 3ag3A-4hq1A:
undetectable
3ag3J-4hq1A:
undetectable
3ag3A-4hq1A:
22.32
3ag3J-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 11 LEU A 180
SER A 155
VAL A 130
VAL A 172
TRP A 150
None
1.45A 3aqiA-4hq1A:
undetectable
3aqiA-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.26A 3aqiB-4hq1A:
undetectable
3aqiB-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 VAL A 237
LEU A 239
VAL A 211
GLY A 233
LEU A 228
None
1.02A 3nt1A-4hq1A:
undetectable
3nt1A-4hq1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 VAL A 237
LEU A 239
VAL A 211
GLY A 233
LEU A 228
None
0.99A 3nt1B-4hq1A:
undetectable
3nt1B-4hq1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 VAL A 237
LEU A 239
VAL A 211
GLY A 233
LEU A 228
None
1.01A 3pghC-4hq1A:
undetectable
3pghC-4hq1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 VAL A 237
LEU A 239
VAL A 211
GLY A 233
LEU A 228
None
1.01A 3pghD-4hq1A:
undetectable
3pghD-4hq1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 5 THR A 437
GLY A 439
PRO A 441
ASN A 440
None
1.19A 3u8qA-4hq1A:
undetectable
3u8qA-4hq1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.22A 3w1wA-4hq1A:
undetectable
3w1wA-4hq1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
None
1.20A 3w1wB-4hq1A:
undetectable
3w1wB-4hq1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 6 ILE A 225
MET A 231
THR A 232
LEU A 234
None
1.02A 3wg7N-4hq1A:
undetectable
3wg7W-4hq1A:
undetectable
3wg7N-4hq1A:
22.32
3wg7W-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
None
1.06A 4fp9A-4hq1A:
undetectable
4fp9A-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
None
1.06A 4fp9C-4hq1A:
undetectable
4fp9C-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
None
1.07A 4fp9D-4hq1A:
undetectable
4fp9D-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 GLY A 424
GLY A 444
ASN A 420
LEU A 393
GLY A 394
None
1.07A 4fp9F-4hq1A:
undetectable
4fp9F-4hq1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4jksA-4hq1A:
undetectable
4jksA-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.02A 4jksB-4hq1A:
undetectable
4jksB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.02A 4k8cA-4hq1A:
undetectable
4k8cA-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4k8cB-4hq1A:
undetectable
4k8cB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4k8kA-4hq1A:
undetectable
4k8kA-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.04A 4k8kB-4hq1A:
undetectable
4k8kB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4kahA-4hq1A:
undetectable
4kahA-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4kahB-4hq1A:
undetectable
4kahB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4kalB-4hq1A:
undetectable
4kalB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.01A 4kanA-4hq1A:
undetectable
4kanA-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.01A 4kanB-4hq1A:
undetectable
4kanB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.04A 4kbeA-4hq1A:
undetectable
4kbeA-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4kbeB-4hq1A:
undetectable
4kbeB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4lbgA-4hq1A:
undetectable
4lbgA-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.02A 4lbgB-4hq1A:
undetectable
4lbgB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4lcaA-4hq1A:
undetectable
4lcaA-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ILE A 443
GLY A 424
GLY A 444
ILE A 402
THR A 437
None
1.03A 4lcaB-4hq1A:
undetectable
4lcaB-4hq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 8 SER A 241
GLY A 218
TRP A 238
PHE A 195
None
0.80A 5albL-4hq1A:
undetectable
5albL-4hq1A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 6 LEU A 214
PRO A 182
PHE A 185
GLU A 184
None
None
None
FUC  A 505 (-3.5A)
1.23A 5b8iA-4hq1A:
undetectable
5b8iA-4hq1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
3 / 3 GLU A 141
TRP A  97
ASN A 168
None
1.09A 5dv4A-4hq1A:
undetectable
5dv4A-4hq1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ALA A 384
ILE A 392
SER A 387
ILE A 331
LEU A 415
None
1.14A 5h8tA-4hq1A:
undetectable
5h8tA-4hq1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ALA A 384
ILE A 392
SER A 387
ILE A 331
LEU A 415
None
1.19A 5hbsA-4hq1A:
undetectable
5hbsA-4hq1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 ASP A 124
LEU A  35
LEU A  95
LEU A  84
PRO A 127
None
1.21A 5hnyB-4hq1A:
undetectable
5hnyB-4hq1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 VAL A 237
LEU A 239
VAL A 211
GLY A 233
LEU A 228
None
1.06A 5jvzA-4hq1A:
undetectable
5jvzA-4hq1A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 MET A 204
LEU A 180
LEU A 216
ILE A 225
LEU A 239
None
1.25A 5toaB-4hq1A:
undetectable
5toaB-4hq1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 4 LEU A 110
GLY A 109
SER A 108
SER A 106
None
1.33A 5uunA-4hq1A:
undetectable
5uunA-4hq1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 4 LEU A 254
GLY A 253
SER A 252
SER A 274
None
1.06A 5uunA-4hq1A:
undetectable
5uunA-4hq1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 4 LEU A 110
GLY A 109
SER A 108
SER A 106
None
1.25A 5uunB-4hq1A:
undetectable
5uunB-4hq1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 4 LEU A 254
GLY A 253
SER A 252
SER A 274
None
0.98A 5uunB-4hq1A:
undetectable
5uunB-4hq1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 6 ILE A 225
MET A 231
THR A 232
LEU A 234
None
1.02A 5z86N-4hq1A:
undetectable
5z86W-4hq1A:
undetectable
5z86N-4hq1A:
22.32
5z86W-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 6 ILE A 225
MET A 231
THR A 232
LEU A 234
None
1.03A 5zcoN-4hq1A:
undetectable
5zcoW-4hq1A:
undetectable
5zcoN-4hq1A:
22.32
5zcoW-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 7 ILE A  71
LEU A  95
THR A  67
LEU A  90
None
0.98A 5zcpA-4hq1A:
undetectable
5zcpJ-4hq1A:
undetectable
5zcpA-4hq1A:
22.32
5zcpJ-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
5 / 12 GLY A 376
LEU A 398
GLY A 400
ASP A 224
ASN A 397
None
1.13A 6mhtA-4hq1A:
undetectable
6mhtA-4hq1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 7 ILE A  71
LEU A  95
THR A  67
LEU A  90
None
0.95A 6nmpA-4hq1A:
undetectable
6nmpJ-4hq1A:
undetectable
6nmpA-4hq1A:
22.32
6nmpJ-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana)
4 / 5 ILE A  71
LEU A  95
THR A  67
LEU A  90
None
0.87A 6nmpN-4hq1A:
undetectable
6nmpW-4hq1A:
undetectable
6nmpN-4hq1A:
22.32
6nmpW-4hq1A:
7.68