SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 9 GLY A 486
GLY A 458
SER A 456
GLU A 457
GLY A 463
 None
 1.24A 1l5kA-4hq6A:
undetectable		 1l5kA-4hq6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 11 GLY A 373
PRO A 375
GLU A 356
VAL A 558
TYR A 560
 None
 1.45A 2fl5A-4hq6A:
undetectable
2fl5B-4hq6A:
undetectable
2fl5F-4hq6A:
1.6		 2fl5A-4hq6A:
18.26
2fl5B-4hq6A:
16.93
2fl5F-4hq6A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 8 PRO A 374
VAL A 561
SER A 562
ALA A 608
 None
 1.13A 2v41G-4hq6A:
undetectable
2v41H-4hq6A:
undetectable		 2v41G-4hq6A:
17.80
2v41H-4hq6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 TRP A 351
VAL A 648
ARG A 710
 None
 0.93A 3b0wA-4hq6A:
undetectable		 3b0wA-4hq6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 11 TYR A 568
ALA A 498
ILE A 538
ALA A 539
ASP A 573
 None
 1.12A 3nmuB-4hq6A:
undetectable
3nmuJ-4hq6A:
undetectable		 3nmuB-4hq6A:
21.24
3nmuJ-4hq6A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 TYR A 329
TYR A 310
GLU A 302
 None
 0.85A 3pfgA-4hq6A:
2.6		 3pfgA-4hq6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		3 / 3 ARG A 281
TYR A 683
ASN A 673
 None
 0.95A 4ffwB-4hq6A:
undetectable		 4ffwB-4hq6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 9 GLY A 486
GLY A 458
SER A 456
GLU A 457
GLY A 463
 None
 1.33A 4kqiA-4hq6A:
undetectable		 4kqiA-4hq6A:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 7 LYS A 529
ASN A 582
ARG A 584
GLN A 586
VAL A 587
 None
 0.95A 4mv7A-4hq6A:
37.9		 4mv7A-4hq6A:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 7 LYS A 529
ASN A 582
ARG A 584
VAL A 587
GLU A 588
 None
 1.18A 4mv7A-4hq6A:
37.9		 4mv7A-4hq6A:
32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 11 LEU A 554
ARG A 553
GLU A 567
LEU A 581
GLU A 502
 None
 1.13A 4wg0J-4hq6A:
undetectable
4wg0K-4hq6A:
undetectable
4wg0L-4hq6A:
undetectable		 4wg0J-4hq6A:
2.32
4wg0K-4hq6A:
2.32
4wg0L-4hq6A:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 12 TRP A 351
SER A 685
THR A 668
ALA A 308
TYR A 683
 None
 1.41A 6drxA-4hq6A:
undetectable		 6drxA-4hq6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 12 GLY A 518
SER A 515
TYR A 623
LEU A 622
ILE A 595
 None
 1.41A 6md4A-4hq6A:
undetectable		 6md4A-4hq6A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		4 / 8 ASP A 750
HIS A 647
GLU A 533
ASP A 520
 None
 1.17A 6mn4A-4hq6A:
undetectable		 6mn4A-4hq6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens) 		5 / 12 GLY A 432
GLY A 404
GLN A 393
VAL A 390
ALA A 443
 None
 1.09A 6nj9K-4hq6A:
undetectable		 6nj9K-4hq6A:
23.28