SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4hqe TRANSCRIPTIONAL
REGULATOR QSRR
(Staphylococcus
aureus) 		5 / 12 GLY A  85
LYS A  84
LEU A  64
LEU A  92
ALA A  91
 None
 0.99A 1gseB-4hqeA:
undetectable		 1gseB-4hqeA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4hqe TRANSCRIPTIONAL
REGULATOR QSRR
(Staphylococcus
aureus) 		3 / 3 GLU A  10
THR A  11
LEU A  64
 None
 0.69A 1v8bC-4hqeA:
undetectable		 1v8bC-4hqeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4hqe TRANSCRIPTIONAL
REGULATOR QSRR
(Staphylococcus
aureus) 		5 / 12 ASN A  20
ILE A  23
ILE A  24
LEU A  27
ALA A  60
 None
 0.75A 3rukB-4hqeA:
undetectable		 3rukB-4hqeA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4hqe TRANSCRIPTIONAL
REGULATOR QSRR
(Staphylococcus
aureus) 		5 / 12 ASN A  20
ILE A  23
ILE A  24
LEU A  27
ALA A  60
 None
 0.83A 4nkvB-4hqeA:
undetectable		 4nkvB-4hqeA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4hqe TRANSCRIPTIONAL
REGULATOR QSRR
(Staphylococcus
aureus) 		3 / 3 LEU A  81
LEU A  64
TRP A  62
 None
 0.71A 5nwuA-4hqeA:
undetectable		 5nwuA-4hqeA:
16.36