SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 6 GLY A 189
GLY A 185
TYR A 213
SER A  54
 None
None
None
MN  A 301 (-2.1A)
 0.90A 1eswA-4hqnA:
undetectable		 1eswA-4hqnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 ILE A  82
LEU A  71
SER A  74
LEU A 152
ILE A 154
 None
 1.18A 1fmlB-4hqnA:
undetectable		 1fmlB-4hqnA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 THR A  94
LEU A 117
TYR A 121
GLY A  51
GLY A  90
 None
 1.21A 1httB-4hqnA:
4.0		 1httB-4hqnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 THR A  94
LEU A 117
TYR A 121
GLY A  51
GLY A  90
 None
 1.27A 1httC-4hqnA:
3.1		 1httC-4hqnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 THR A  94
LEU A 117
TYR A 121
GLY A  51
GLY A  90
 None
 1.26A 1httD-4hqnA:
4.0		 1httD-4hqnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 GLY A 187
GLN A 188
VAL A 160
SER A  52
 None
None
None
MN  A 301 (-2.2A)
 1.45A 1p6kB-4hqnA:
undetectable		 1p6kB-4hqnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 GLY A 187
GLN A 188
VAL A 160
SER A  52
 None
None
None
MN  A 301 (-2.2A)
 1.49A 1rs6B-4hqnA:
1.3		 1rs6B-4hqnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 SER A  52
SER A  54
THR A 127
ASN A 162
 MN  A 301 (-2.2A)
MN  A 301 (-2.1A)
MN  A 301 ( 2.7A)
CL  A 304 (-4.8A)
 0.90A 1yvpA-4hqnA:
11.4		 1yvpA-4hqnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 GLY A 187
GLN A 188
VAL A 160
SER A  52
 None
None
None
MN  A 301 (-2.2A)
 1.43A 1zzuB-4hqnA:
1.3		 1zzuB-4hqnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.00A 2aylA-4hqnA:
undetectable		 2aylA-4hqnA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.09A 2aylB-4hqnA:
undetectable		 2aylB-4hqnA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 7 ILE A 227
GLY A  70
MET A  67
TRP A 216
 None
 1.25A 2pnjB-4hqnA:
4.6		 2pnjB-4hqnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 GLN A 151
ALA A 149
GLN A  42
ILE A 150
 None
 1.36A 2z0aA-4hqnA:
undetectable		 2z0aA-4hqnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 THR A 127
GLY A  90
ILE A  55
LEU A  88
THR A 157
 MN  A 301 ( 2.7A)
None
None
None
None
 1.14A 3eeyH-4hqnA:
2.2		 3eeyH-4hqnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 THR A 127
GLY A  90
ILE A  55
LEU A  88
THR A 157
 MN  A 301 ( 2.7A)
None
None
None
None
 1.17A 3eeyI-4hqnA:
2.4		 3eeyI-4hqnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 GLY A 125
ASN A 162
GLY A  53
SER A  52
GLY A  51
 None
CL  A 304 (-4.8A)
None
MN  A 301 (-2.2A)
None
 1.05A 3huoB-4hqnA:
undetectable		 3huoB-4hqnA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.07A 3n8zA-4hqnA:
undetectable		 3n8zA-4hqnA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.04A 3pghA-4hqnA:
undetectable		 3pghA-4hqnA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.05A 3pghD-4hqnA:
undetectable		 3pghD-4hqnA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 ASP A 158
GLY A  51
GLY A  53
SER A  54
LEU A  48
 MN  A 301 ( 4.0A)
None
None
MN  A 301 (-2.1A)
None
 1.07A 4blvB-4hqnA:
undetectable		 4blvB-4hqnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 9 GLY A  53
SER A  54
TYR A 121
ASP A  50
GLY A 125
 None
MN  A 301 (-2.1A)
None
MN  A 301 ( 4.1A)
None
 1.44A 4lb0A-4hqnA:
undetectable		 4lb0A-4hqnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 9 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.04A 4rs0A-4hqnA:
undetectable		 4rs0A-4hqnA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 GLY A 256
ARG A 255
GLY A 254
GLU A 278
 None
 1.13A 4z2eB-4hqnA:
undetectable
4z2eC-4hqnA:
2.5		 4z2eB-4hqnA:
20.04
4z2eC-4hqnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.09A 5ikrB-4hqnA:
undetectable		 5ikrB-4hqnA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 LEU A 168
LEU A 133
GLY A 200
ALA A 199
LEU A 181
 None
 1.07A 5jw1B-4hqnA:
undetectable		 5jw1B-4hqnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 12 LEU A  88
VAL A 114
LEU A 117
ILE A 186
LEU A  71
 None
 1.15A 5og9B-4hqnA:
undetectable		 5og9B-4hqnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 GLY A 187
GLN A 188
VAL A 160
SER A  52
 None
None
None
MN  A 301 (-2.2A)
 1.46A 5vunA-4hqnA:
undetectable		 5vunA-4hqnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 VAL A  64
PRO A 123
GLY A  56
TYR A  57
 None
 1.25A 5x80A-4hqnA:
undetectable
5x80B-4hqnA:
undetectable		 5x80A-4hqnA:
17.83
5x80B-4hqnA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		4 / 5 PRO A 123
GLY A  56
TYR A  57
VAL A  64
 None
 1.30A 5x80C-4hqnA:
undetectable
5x80D-4hqnA:
undetectable		 5x80C-4hqnA:
17.83
5x80D-4hqnA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 9 VAL A  49
VAL A 114
GLY A  70
LEU A  71
VAL A  64
 None
 1.25A 6czmA-4hqnA:
undetectable
6czmB-4hqnA:
undetectable		 6czmA-4hqnA:
20.56
6czmB-4hqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 9 VAL A  49
VAL A 114
GLY A  70
LEU A  71
VAL A  64
 None
 1.20A 6czmB-4hqnA:
undetectable
6czmC-4hqnA:
undetectable		 6czmB-4hqnA:
20.56
6czmC-4hqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 9 VAL A  49
VAL A 114
GLY A  70
LEU A  71
VAL A  64
 None
 1.17A 6czmD-4hqnA:
undetectable
6czmE-4hqnA:
undetectable		 6czmD-4hqnA:
20.56
6czmE-4hqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4hqn SPOROZOITE SURFACE
PROTEIN 2
(Plasmodium
vivax) 		5 / 10 VAL A  49
VAL A 114
GLY A  70
LEU A  71
VAL A  64
 None
 1.20A 6czmE-4hqnA:
undetectable
6czmF-4hqnA:
undetectable		 6czmE-4hqnA:
20.56
6czmF-4hqnA:
20.56