SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.74A 1uw6A-4hqpA:
26.3
1uw6B-4hqpA:
26.7		 1uw6A-4hqpA:
60.66
1uw6B-4hqpA:
60.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.73A 1uw6D-4hqpA:
26.2
1uw6E-4hqpA:
26.6		 1uw6D-4hqpA:
60.66
1uw6E-4hqpA:
60.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.76A 1uw6G-4hqpA:
26.3
1uw6H-4hqpA:
26.5		 1uw6G-4hqpA:
60.66
1uw6H-4hqpA:
60.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.74A 1uw6P-4hqpA:
26.5
1uw6Q-4hqpA:
26.4		 1uw6P-4hqpA:
60.66
1uw6Q-4hqpA:
60.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.70A 1uw6P-4hqpA:
26.5
1uw6T-4hqpA:
26.2		 1uw6P-4hqpA:
60.66
1uw6T-4hqpA:
60.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 7 TYR A  91
TRP A 145
TYR A 184
TYR A 191
 None
 0.60A 2xytD-4hqpA:
19.3		 2xytD-4hqpA:
36.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 7 TYR A  91
TRP A 145
TYR A 184
TYR A 191
 None
 0.57A 2xytG-4hqpA:
26.0		 2xytG-4hqpA:
36.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 7 TYR A  91
TRP A 145
TYR A 184
TYR A 191
 None
 0.63A 2xytH-4hqpA:
26.2		 2xytH-4hqpA:
36.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 4 ARG A 179
ASP A 193
LEU A  88
ARG A 150
 None
 1.26A 2ziaB-4hqpA:
undetectable		 2ziaB-4hqpA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PMZ_E_TUBE220_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 7 TYR A  91
LYS A 141
TRP A 145
TYR A 191
 None
 0.82A 3pmzE-4hqpA:
25.6		 3pmzE-4hqpA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PMZ_E_TUBE220_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 7 TYR A  91
TRP A 145
TYR A 184
TYR A 191
 None
 0.72A 3pmzE-4hqpA:
25.6		 3pmzE-4hqpA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 7 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.60A 3wipA-4hqpA:
26.7
3wipB-4hqpA:
25.6		 3wipA-4hqpA:
57.52
3wipB-4hqpA:
57.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.64A 3wipB-4hqpA:
25.6
3wipC-4hqpA:
26.8		 3wipB-4hqpA:
57.52
3wipC-4hqpA:
57.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.58A 3wipC-4hqpA:
26.8
3wipD-4hqpA:
26.9		 3wipC-4hqpA:
57.52
3wipD-4hqpA:
57.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.60A 3wipD-4hqpA:
26.9
3wipE-4hqpA:
26.8		 3wipD-4hqpA:
57.52
3wipE-4hqpA:
57.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.58A 3wipA-4hqpA:
26.7
3wipE-4hqpA:
26.8		 3wipA-4hqpA:
57.52
3wipE-4hqpA:
57.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 7 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.63A 3wipF-4hqpA:
26.8
3wipG-4hqpA:
27.2		 3wipF-4hqpA:
57.52
3wipG-4hqpA:
57.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.58A 3wipG-4hqpA:
27.2
3wipH-4hqpA:
26.8		 3wipG-4hqpA:
57.52
3wipH-4hqpA:
57.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		3 / 3 ASP A 131
ARG A 169
LYS A 202
 None
 1.01A 3wipG-4hqpA:
27.2		 3wipG-4hqpA:
57.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.63A 3wipF-4hqpA:
26.8
3wipJ-4hqpA:
26.2		 3wipF-4hqpA:
57.52
3wipJ-4hqpA:
57.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		5 / 12 SER A 144
ASP A  87
ILE A  19
PRO A  20
GLN A  22
 None
 1.13A 4uroA-4hqpA:
undetectable		 4uroA-4hqpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		5 / 12 SER A 144
ASP A  87
ILE A  19
PRO A  20
GLN A  22
 None
 1.15A 4uroB-4hqpA:
undetectable		 4uroB-4hqpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		5 / 12 VAL A  50
ASP A  49
LEU A 116
GLN A 103
ARG A 122
 None
 1.37A 5syfB-4hqpA:
undetectable		 5syfB-4hqpA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 8 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.61A 6cnjD-4hqpA:
20.9
6cnjE-4hqpA:
22.2		 6cnjD-4hqpA:
17.01
6cnjE-4hqpA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis) 		4 / 6 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.48A 6cnkA-4hqpA:
20.4
6cnkB-4hqpA:
14.8		 6cnkA-4hqpA:
17.01
6cnkB-4hqpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens) 		4 / 5 SER A 180
ARG A 182
ASP A 193
LYS A 141
 None
 1.44A 6dwdA-4hqpA:
undetectable		 6dwdA-4hqpA:
17.94