SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 4hqs THIOREDOXIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 LEU A  57
ALA A 101
VAL A 110
TYR A  70
LEU A  77
 None
None
MG  A 205 (-4.7A)
None
None
 1.44A 1aqbA-4hqsA:
undetectable		 1aqbA-4hqsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4hqs THIOREDOXIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 THR A 109
SER A  90
LEU A  91
THR A  94
 None
 0.81A 3deuB-4hqsA:
undetectable		 3deuB-4hqsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4hqs THIOREDOXIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 120
GLN A 119
PHE A 124
 None
MG  A 209 ( 4.4A)
None
 0.79A 3g4lC-4hqsA:
undetectable		 3g4lC-4hqsA:
15.49