SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_A_SAMA1500_0 (ASPARTOKINASE)	4hr1	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi virus 1)	4 / 8	ILE B 77 ARG B 63 LEU B 69 GLU B 73	None	0.98A	2cdqA-4hr1B: 0.4	2cdqA-4hr1B: 15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB151_0 (ILEAL BILE ACID-BINDING PROTEIN)	4hr1	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi virus 1)	5 / 10	ILE B 91 ILE B 92 GLY B 106 VAL B 98 LEU B 114	None	1.36A	3elzB-4hr1B: undetectable	3elzB-4hr1B: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EUM_B_ACTB603_0 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	4hr1	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi virus 1)	4 / 4	ALA B 50 ASN B 54 ARG B 16 ILE B 12	None	0.96A	5eumB-4hr1B: undetectable	5eumB-4hr1B: 17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T8H_B_478B401_2 (PROTEASE)	4hr1	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi virus 1)	6 / 12	LEU B 15 ALA B 50 ILE B 9 VAL B 57 ILE B 77 ILE B 12	None	1.36A	5t8hB-4hr1B: undetectable	5t8hB-4hr1B: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DYO_A_LDPA901_0 (EBONY)	4hr1	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi virus 1)	4 / 5	GLU B 89 VAL B 93 LEU B 96 THR B 107	None	1.16A	6dyoA-4hr1B: undetectable	6dyoA-4hr1B: 19.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2CDQ_A_SAMA1500_0","ASPARTOKINASE","4hr1","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi virus 1",4,"ILE B  77;ARG B  63;LEU B  69;GLU B  73","None","0.98A","2cdqA-4hr1B:0.4","2cdqA-4hr1B:15.66"],["3ELZ_B_CHDB151_0","ILEAL BILE ACID-BINDING PROTEIN","4hr1","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi virus 1",5,"ILE B  91;ILE B  92;GLY B 106;VAL B  98;LEU B 114","None","1.36A","3elzB-4hr1B:undetectable","3elzB-4hr1B:22.37"],["5EUM_B_ACTB603_0","LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA","4hr1","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi virus 1",4,"ALA B  50;ASN B  54;ARG B  16;ILE B  12","None","0.96A","5eumB-4hr1B:undetectable","5eumB-4hr1B:17.49"],["5T8H_B_478B401_2","PROTEASE","4hr1","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi virus 1",6,"LEU B  15;ALA B  50;ILE B   9;VAL B  57;ILE B  77;ILE B  12","None","1.36A","5t8hB-4hr1B:undetectable","5t8hB-4hr1B:22.73"],["6DYO_A_LDPA901_0","EBONY","4hr1","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi virus 1",4,"GLU B  89;VAL B  93;LEU B  96;THR B 107","None","1.16A","6dyoA-4hr1B:undetectable","6dyoA-4hr1B:19.84"]]