SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hr3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 5 THR A 102
THR A 178
HIS A 234
HIS A 271
 None
FAD  A 501 (-3.9A)
FAD  A 501 (-4.2A)
None
 1.45A 1d4fD-4hr3A:
undetectable		 1d4fD-4hr3A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 9 VAL A 242
ILE A 216
ILE A 189
VAL A 168
ILE A 170
 None
 1.01A 1ohrB-4hr3A:
undetectable		 1ohrB-4hr3A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 TRP A 175
VAL A 237
TRP A 176
 None
None
FAD  A 501 (-4.5A)
 1.34A 2xdcC-4hr3A:
undetectable
2xdcD-4hr3A:
undetectable		 2xdcC-4hr3A:
4.10
2xdcD-4hr3A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 TRP A 175
VAL A 237
TRP A 176
 None
None
FAD  A 501 (-4.5A)
 1.28A 2xdcE-4hr3A:
undetectable
2xdcF-4hr3A:
undetectable		 2xdcE-4hr3A:
4.10
2xdcF-4hr3A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 TRP A 175
VAL A 237
TRP A 176
 None
None
FAD  A 501 (-4.5A)
 1.32A 2y6nC-4hr3A:
undetectable
2y6nD-4hr3A:
undetectable		 2y6nC-4hr3A:
4.10
2y6nD-4hr3A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 TRP A 175
VAL A 237
TRP A 176
 None
None
FAD  A 501 (-4.5A)
 1.33A 2y6nE-4hr3A:
undetectable
2y6nF-4hr3A:
undetectable		 2y6nE-4hr3A:
4.10
2y6nF-4hr3A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 VAL A  16
GLY A 277
LEU A 278
PRO A 101
ILE A  20
 None
 0.97A 3em6B-4hr3A:
undetectable		 3em6B-4hr3A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 233
GLY A 232
PRO A 231
ALA A 141
ASP A 110
 None
 1.13A 3i5uA-4hr3A:
undetectable		 3i5uA-4hr3A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 233
GLY A 232
PRO A 231
ALA A 141
ASP A 110
 None
 1.14A 3i5uB-4hr3A:
undetectable		 3i5uB-4hr3A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 10 LEU A 130
ASN A 113
VAL A 116
GLY A 112
LEU A 134
 None
 1.46A 3lp1A-4hr3A:
undetectable		 3lp1A-4hr3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 265
ALA A 342
ALA A 339
LEU A 331
SER A 111
 None
 1.11A 3mteA-4hr3A:
undetectable		 3mteA-4hr3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 TRP A 175
VAL A 237
TRP A 176
 None
None
FAD  A 501 (-4.5A)
 1.18A 3zq8A-4hr3A:
undetectable
3zq8B-4hr3A:
undetectable		 3zq8A-4hr3A:
4.10
3zq8B-4hr3A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
 None
 1.07A 4fp9A-4hr3A:
undetectable		 4fp9A-4hr3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
 None
 1.06A 4fp9C-4hr3A:
undetectable		 4fp9C-4hr3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
 None
 1.08A 4fp9D-4hr3A:
undetectable		 4fp9D-4hr3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 PRO A  74
GLY A  81
ASN A 105
LEU A 133
GLY A 136
 None
 1.08A 4fzvA-4hr3A:
undetectable		 4fzvA-4hr3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 7 ASP A 247
PRO A 210
VAL A 128
GLU A 124
 None
 1.11A 4hvrA-4hr3A:
undetectable		 4hvrA-4hr3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 10 ILE A 188
VAL A 237
GLY A 172
VAL A 207
VAL A 209
 None
 0.94A 4j5jB-4hr3A:
undetectable		 4j5jB-4hr3A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		5 / 12 VAL A 103
LEU A  56
LEU A  32
VAL A  27
SER A  97
 None
 1.12A 4rrxB-4hr3A:
undetectable		 4rrxB-4hr3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 MET A 360
GLU A 308
ARG A 309
 None
 0.99A 5tjyA-4hr3A:
undetectable		 5tjyA-4hr3A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		3 / 3 MET A 360
GLU A 308
ARG A 309
 None
 0.91A 5tjzA-4hr3A:
undetectable		 5tjzA-4hr3A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 6 ASN A 105
PHE A  72
LEU A 130
SER A 140
 None
 1.46A 6a7pB-4hr3A:
undetectable		 6a7pB-4hr3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE
(Mycobacteroides
abscessus) 		4 / 6 ARG A 139
MET A 114
ASN A 113
ASP A 110
 None
 1.48A 6dhbA-4hr3A:
undetectable		 6dhbA-4hr3A:
12.44