SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4hr6 LECTIN
(Trichosanthes
anguina) 		4 / 7 LEU C  80
THR C  53
TRP C  87
ASN C  97
 None
 1.39A 1afsA-4hr6C:
undetectable		 1afsA-4hr6C:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4hr6 LECTIN
(Trichosanthes
anguina) 		4 / 7 LEU C  80
THR C  53
TRP C  87
ASN C  97
 None
 1.39A 1afsB-4hr6C:
undetectable		 1afsB-4hr6C:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4hr6 LECTIN
(Trichosanthes
anguina) 		3 / 3 LEU C 105
SER C 107
ASN C 115
 None
 0.79A 1bx4A-4hr6C:
undetectable		 1bx4A-4hr6C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4hr6 LECTIN
(Trichosanthes
anguina) 		5 / 12 LEU C 262
ALA B 240
LEU C 175
ILE C 225
ILE C 181
 None
 0.90A 1fk6A-4hr6C:
undetectable		 1fk6A-4hr6C:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hr6 LECTIN
LECTIN
(Trichosanthes
anguina;
Trichosanthes
anguina) 		3 / 3 LYS B 179
ASP C 236
ASP C 146
 None
AMG  C 302 (-2.9A)
None
 0.99A 2br4D-4hr6B:
undetectable		 2br4D-4hr6B:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4hr6 LECTIN
(Trichosanthes
anguina) 		4 / 7 SER C 124
ALA C 125
SER C 126
SER C 212
 None
 0.60A 2i91A-4hr6C:
undetectable		 2i91A-4hr6C:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4hr6 LECTIN
(Trichosanthes
anguina) 		4 / 7 SER C 124
ALA C 125
SER C 126
SER C 212
 None
 0.60A 2i91B-4hr6C:
undetectable		 2i91B-4hr6C:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4hr6 LECTIN
(Trichosanthes
anguina) 		4 / 5 LEU B 117
ALA B 121
LEU B 152
MET B 160
 None
 1.22A 2oaxA-4hr6B:
undetectable		 2oaxA-4hr6B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4hr6 LECTIN
(Trichosanthes
anguina) 		3 / 3 MET C 148
GLU C 151
ASP C 154
 None
 1.07A 3a25A-4hr6C:
undetectable		 3a25A-4hr6C:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4hr6 LECTIN
(Trichosanthes
anguina) 		5 / 12 LEU B  53
LEU B  65
TYR B  51
ILE B  67
ALA B  76
 None
 1.04A 3gwvA-4hr6B:
undetectable		 3gwvA-4hr6B:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4hr6 LECTIN
(Trichosanthes
anguina) 		4 / 8 ASP B 136
SER B  57
ASP B 133
ASP B  60
 None
 0.94A 3havA-4hr6B:
undetectable		 3havA-4hr6B:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 4hr6 LECTIN
LECTIN
(Trichosanthes
anguina;
Trichosanthes
anguina) 		5 / 12 SER B 165
GLY A  21
ILE B  63
TYR B  51
LEU B  53
 None
 1.43A 3iizA-4hr6B:
undetectable		 3iizA-4hr6B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4hr6 LECTIN
(Trichosanthes
anguina) 		5 / 12 ILE B 157
VAL B 156
SER B 153
THR B 183
ILE B 139
 None
 1.14A 3vrjA-4hr6B:
undetectable
3vrjC-4hr6B:
undetectable		 3vrjA-4hr6B:
20.64
3vrjC-4hr6B:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4hr6 LECTIN
(Trichosanthes
anguina) 		3 / 3 ASP C  21
GLY C  24
TYR C  36
 AMG  C 301 (-2.8A)
AMG  C 301 (-3.7A)
AMG  C 301 (-3.6A)
 0.45A 3w9tC-4hr6C:
10.8		 3w9tC-4hr6C:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4hr6 LECTIN
(Trichosanthes
anguina) 		3 / 3 ASP C  21
GLY C  24
TYR C  36
 AMG  C 301 (-2.8A)
AMG  C 301 (-3.7A)
AMG  C 301 (-3.6A)
 0.45A 3w9tG-4hr6C:
11.0		 3w9tG-4hr6C:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 4hr6 LECTIN
LECTIN
(Trichosanthes
anguina;
Trichosanthes
anguina) 		5 / 12 SER B 165
GLY A  21
ILE B  63
TYR B  51
LEU B  53
 None
 1.42A 4jxcA-4hr6B:
undetectable		 4jxcA-4hr6B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4hr6 LECTIN
(Trichosanthes
anguina) 		5 / 12 VAL C  89
VAL C  91
PHE C  48
SER B 232
GLY B 212
 None
 0.99A 4mm4B-4hr6C:
undetectable		 4mm4B-4hr6C:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4hr6 LECTIN
(Trichosanthes
anguina) 		5 / 10 ASP C  16
TYR C 176
GLY C 211
SER C 177
GLY C 179
 None
 1.15A 4mmdA-4hr6C:
undetectable		 4mmdA-4hr6C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4hr6 LECTIN
(Trichosanthes
anguina) 		5 / 12 ASP C  16
TYR C 176
GLY C 211
SER C 177
GLY C 179
 None
 1.13A 4mmdB-4hr6C:
undetectable		 4mmdB-4hr6C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4hr6 LECTIN
(Trichosanthes
anguina) 		5 / 12 GLY C  52
PHE C  48
ASN C  97
ILE C  74
LEU C  33
 None
 1.25A 4n48A-4hr6C:
undetectable		 4n48A-4hr6C:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4hr6 LECTIN
(Trichosanthes
anguina) 		5 / 12 GLY C  52
PHE C  48
ASN C  97
ILE C  74
LEU C  33
 None
 1.20A 4n48B-4hr6C:
undetectable		 4n48B-4hr6C:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4hr6 LECTIN
(Trichosanthes
anguina) 		3 / 3 THR B  98
ASN B  90
PHE B  88
 None
 0.84A 4pd9A-4hr6B:
undetectable		 4pd9A-4hr6B:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4hr6 LECTIN
(Trichosanthes
anguina) 		3 / 3 ARG C 216
ASN C 121
ASP C  88
 None
 0.81A 5gwxA-4hr6C:
undetectable		 5gwxA-4hr6C:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4hr6 LECTIN
LECTIN
LECTIN
(Trichosanthes
anguina;
Trichosanthes
anguina;
Trichosanthes
anguina) 		4 / 7 TYR A  35
THR B 208
VAL C 131
TYR B 234
 None
 0.85A 5ov9A-4hr6A:
undetectable		 5ov9A-4hr6A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4hr6 LECTIN
LECTIN
LECTIN
(Trichosanthes
anguina;
Trichosanthes
anguina;
Trichosanthes
anguina) 		4 / 8 TYR A  35
THR B 208
VAL C 131
TYR B 234
 None
 0.85A 5ov9B-4hr6A:
undetectable		 5ov9B-4hr6A:
6.70