SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_A_PNNA304_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	4hr7	BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE (Escherichia coli)	4 / 4	GLN B 144 PRO B 145 VAL B 146 GLU B 147	None	1.23A	3huoA-4hr7B: undetectable	3huoA-4hr7B: 21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_A_SALA301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	4hr7	BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE (Escherichia coli)	4 / 8	VAL B 146 ARG B 84 VAL B 83 ILE B 127	None	0.99A	3remA-4hr7B: undetectable	3remA-4hr7B: 22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_B_SALB301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	4hr7	BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE (Escherichia coli)	4 / 8	VAL B 146 ARG B 84 VAL B 83 ILE B 127	None	1.03A	3remB-4hr7B: undetectable	3remB-4hr7B: 22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_1_BEZ1801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	4hr7	BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE (Escherichia coli)	3 / 3	LEU B 139 PHE B 91 ILE B 138	None	0.77A	5dzk1-4hr7B: undetectable 5dzkF-4hr7B: undetectable 5dzkM-4hr7B: undetectable	5dzk1-4hr7B: 6.90 5dzkF-4hr7B: 24.23 5dzkM-4hr7B: 23.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3HUO_A_PNNA304_0","CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE","4hr7","BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE","Escherichia coli",4,"GLN B 144;PRO B 145;VAL B 146;GLU B 147","None","1.23A","3huoA-4hr7B:undetectable","3huoA-4hr7B:21.21"],["3REM_A_SALA301_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","4hr7","BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE","Escherichia coli",4,"VAL B 146;ARG B  84;VAL B  83;ILE B 127","None","0.99A","3remA-4hr7B:undetectable","3remA-4hr7B:22.70"],["3REM_B_SALB301_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","4hr7","BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE","Escherichia coli",4,"VAL B 146;ARG B  84;VAL B  83;ILE B 127","None","1.03A","3remB-4hr7B:undetectable","3remB-4hr7B:22.70"],["5DZK_1_BEZ1801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","4hr7","BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE","Escherichia coli",3,"LEU B 139;PHE B  91;ILE B 138","None","0.77A","5dzk1-4hr7B:undetectable;5dzkF-4hr7B:undetectable;5dzkM-4hr7B:undetectable","5dzk1-4hr7B:6.90;5dzkF-4hr7B:24.23;5dzkM-4hr7B:23.70"]]