SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hrl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29
(synthetic
construct) 		4 / 7 VAL A 105
VAL A 138
ASN A 134
GLY A 135
 None
 1.04A 3kmoB-4hrlA:
undetectable		 3kmoB-4hrlA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29
(synthetic
construct) 		5 / 11 ILE A  62
LEU A  51
HIS A  69
LEU A  67
ALA A  71
 None
 1.05A 4p65E-4hrlA:
undetectable
4p65F-4hrlA:
undetectable
4p65J-4hrlA:
undetectable
4p65L-4hrlA:
undetectable		 4p65E-4hrlA:
5.33
4p65F-4hrlA:
11.73
4p65J-4hrlA:
11.73
4p65L-4hrlA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29
(synthetic
construct) 		5 / 12 VAL A  95
LEU A  83
LEU A 116
ILE A 127
ALA A 136
 None
 1.02A 4p65B-4hrlA:
undetectable
4p65D-4hrlA:
undetectable
4p65I-4hrlA:
undetectable
4p65J-4hrlA:
undetectable		 4p65B-4hrlA:
11.73
4p65D-4hrlA:
11.73
4p65I-4hrlA:
5.33
4p65J-4hrlA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29
(synthetic
construct) 		5 / 12 LEU A 116
VAL A  95
LEU A  83
ILE A 127
ALA A 136
 None
 1.04A 4p65F-4hrlA:
undetectable
4p65H-4hrlA:
undetectable
4p65K-4hrlA:
undetectable
4p65L-4hrlA:
undetectable		 4p65F-4hrlA:
11.73
4p65H-4hrlA:
11.73
4p65K-4hrlA:
5.33
4p65L-4hrlA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29
(synthetic
construct) 		5 / 12 LEU A  83
ALA A 103
ASN A 134
ILE A  94
ALA A  86
 None
 1.30A 5eypB-4hrlA:
undetectable		 5eypB-4hrlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29
(synthetic
construct) 		5 / 12 LEU A  83
ALA A 103
ASN A 134
ILE A  94
ALA A  86
 None
 1.24A 5nm5B-4hrlA:
undetectable		 5nm5B-4hrlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29
(synthetic
construct) 		5 / 12 LEU A  83
ALA A 103
ASN A 134
ILE A  94
ALA A  86
 None
 1.28A 5xiwD-4hrlA:
undetectable		 5xiwD-4hrlA:
19.30