SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hrn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4hrn DESIGNED ANKYRIN
REPEAT PROTEIN
H10-2-G
(synthetic
construct) 		5 / 11 ILE A  95
LEU A  84
HIS A 102
LEU A 100
ALA A 104
 None
 1.08A 4p65E-4hrnA:
undetectable
4p65F-4hrnA:
undetectable
4p65J-4hrnA:
undetectable
4p65L-4hrnA:
undetectable		 4p65E-4hrnA:
7.46
4p65F-4hrnA:
13.91
4p65J-4hrnA:
13.91
4p65L-4hrnA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4hrn DESIGNED ANKYRIN
REPEAT PROTEIN
H10-2-G
(synthetic
construct) 		5 / 10 ALA A  56
PHE A  81
ILE A 119
ALA A 116
ALA A  96
 None
 1.19A 6h1lA-4hrnA:
undetectable		 6h1lA-4hrnA:
14.60