SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hrt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4hrt GLOBIN-2 A CHAIN
(Scapharca
inaequivalvis) 		3 / 3 ALA A  16
VAL A 134
TRP A 138
 None
 0.88A 1c4dA-4hrtA:
undetectable
1c4dB-4hrtA:
undetectable		 1c4dA-4hrtA:
6.29
1c4dB-4hrtA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		4 / 5 SER B  46
THR B  45
GLU B 115
GLY B 114
 None
None
HEM  B 201 ( 4.9A)
None
 1.26A 1icrA-4hrtB:
undetectable
1icrB-4hrtB:
undetectable		 1icrA-4hrtB:
22.62
1icrB-4hrtB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		4 / 5 GLU B 115
GLY B 114
SER B  46
THR B  45
 HEM  B 201 ( 4.9A)
None
None
None
 1.28A 1icrA-4hrtB:
undetectable
1icrB-4hrtB:
undetectable		 1icrA-4hrtB:
22.62
1icrB-4hrtB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		4 / 5 SER B  46
THR B  45
GLU B 115
GLY B 114
 None
None
HEM  B 201 ( 4.9A)
None
 1.24A 1icvC-4hrtB:
undetectable
1icvD-4hrtB:
undetectable		 1icvC-4hrtB:
22.62
1icvD-4hrtB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		4 / 5 GLU B 115
GLY B 114
SER B  46
THR B  45
 HEM  B 201 ( 4.9A)
None
None
None
 1.26A 1icvC-4hrtB:
undetectable
1icvD-4hrtB:
undetectable		 1icvC-4hrtB:
22.62
1icvD-4hrtB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		4 / 5 GLU B 115
GLY B 114
SER B  46
THR B  45
 HEM  B 201 ( 4.9A)
None
None
None
 1.29A 1kqbA-4hrtB:
undetectable
1kqbB-4hrtB:
undetectable		 1kqbA-4hrtB:
21.78
1kqbB-4hrtB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		5 / 11 SER B 142
VAL B 146
LEU B  92
LEU B  20
LEU B  86
 None
 1.21A 2a15A-4hrtB:
undetectable		 2a15A-4hrtB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		5 / 11 LEU B  38
ALA B  40
GLY B  33
LEU B  68
SER B  72
 None
 1.26A 3gyqB-4hrtB:
undetectable		 3gyqB-4hrtB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4hrt GLOBIN-2 A CHAIN
(Scapharca
inaequivalvis) 		4 / 7 PHE A 111
GLY A 112
GLY A 143
PHE A  51
 HEM  A 201 (-3.8A)
None
None
HEM  A 201 (-4.1A)
 0.93A 3ko0M-4hrtA:
undetectable
3ko0P-4hrtA:
undetectable		 3ko0M-4hrtA:
22.88
3ko0P-4hrtA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4hrt GLOBIN-2 A CHAIN
(Scapharca
inaequivalvis) 		5 / 12 VAL A 144
VAL A 145
ALA A 135
LEU A  18
ILE A  14
 None
 0.80A 3ku1H-4hrtA:
undetectable		 3ku1H-4hrtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4hrt GLOBIN-2 A CHAIN
(Scapharca
inaequivalvis) 		5 / 12 THR A 121
PHE A  97
ALA A  98
ILE A 106
ALA A 110
 None
HEM  A 201 (-4.4A)
None
HEM  A 201 (-4.4A)
HEM  A 201 ( 4.8A)
 1.13A 3nxuB-4hrtA:
undetectable		 3nxuB-4hrtA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		5 / 12 LEU B  36
LEU B  68
ALA B  40
ASN B  41
LEU B  42
 None
 0.91A 3r9cA-4hrtB:
undetectable		 3r9cA-4hrtB:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hrt GLOBIN-2 A CHAIN
HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis;
Scapharca
inaequivalvis) 		3 / 3 ARG A  53
LYS B  98
ARG A 104
 HEM  A 201 (-3.8A)
HEM  A 201 (-2.7A)
HEM  A 201 (-3.0A)
 1.43A 3w1wA-4hrtA:
undetectable
3w1wB-4hrtA:
undetectable		 3w1wA-4hrtA:
15.59
3w1wB-4hrtA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hrt GLOBIN-2 A CHAIN
HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis;
Scapharca
inaequivalvis) 		3 / 3 ARG A 104
ARG A  53
LYS B  98
 HEM  A 201 (-3.0A)
HEM  A 201 (-3.8A)
HEM  A 201 (-2.7A)
 1.38A 3w1wA-4hrtA:
undetectable
3w1wB-4hrtA:
undetectable		 3w1wA-4hrtA:
15.59
3w1wB-4hrtA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4hrt GLOBIN-2 A CHAIN
HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		3 / 3 ASN A  78
TRP A  22
ASP B  84
 None
 1.18A 4a7tA-4hrtA:
undetectable
4a7tF-4hrtA:
undetectable		 4a7tA-4hrtA:
21.38
4a7tF-4hrtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4hrt GLOBIN-2 A CHAIN
(Scapharca
inaequivalvis) 		5 / 11 PHE A 111
GLY A 143
ALA A 148
LEU A 149
GLY A 108
 HEM  A 201 (-3.8A)
None
None
None
None
 1.16A 4l6v1-4hrtA:
undetectable
4l6v6-4hrtA:
undetectable		 4l6v1-4hrtA:
11.56
4l6v6-4hrtA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		4 / 5 TYR B  77
THR B 136
LEU B 124
MET B  39
 None
 1.41A 4mbsB-4hrtB:
undetectable		 4mbsB-4hrtB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4hrt GLOBIN-2 A CHAIN
(Scapharca
inaequivalvis) 		4 / 8 PHE A 111
ALA A 148
LEU A 149
GLY A 108
 HEM  A 201 (-3.8A)
None
None
None
 1.02A 4xk8a-4hrtA:
undetectable		 4xk8a-4hrtA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 4hrt GLOBIN-2 A CHAIN
HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		4 / 5 ILE B  73
ARG A  89
CYH A  92
GLU A  95
 None
 1.33A 5fseC-4hrtB:
undetectable		 5fseC-4hrtB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4hrt GLOBIN-2 A CHAIN
(Scapharca
inaequivalvis) 		5 / 9 PHE A 111
GLY A 143
ALA A 148
LEU A 149
GLY A 108
 HEM  A 201 (-3.8A)
None
None
None
None
 1.12A 5l8rA-4hrtA:
1.5		 5l8rA-4hrtA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		5 / 12 LEU B 143
VAL B  95
ARG B  91
SER B  28
THR B  34
 None
 1.22A 5v1tA-4hrtB:
undetectable		 5v1tA-4hrtB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4hrt HEMOGLOBIN B CHAIN
(Scapharca
inaequivalvis) 		4 / 6 ASN B  81
VAL B  83
LEU B  20
GLN B  80
 None
 1.45A 5xdhA-4hrtB:
1.3
5xdhC-4hrtB:
1.6		 5xdhA-4hrtB:
18.00
5xdhC-4hrtB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4hrt GLOBIN-2 A CHAIN
(Scapharca
inaequivalvis) 		5 / 10 LEU A  18
ALA A 137
GLU A  95
PHE A 111
VAL A 115
 None
None
None
HEM  A 201 (-3.8A)
None
 1.31A 6b89A-4hrtA:
undetectable		 6b89A-4hrtA:
20.26