SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION
(Nitrosomonas
europaea) 		4 / 6 ARG A  72
ASN A  40
PRO A  10
ALA A  43
 None
 1.26A 2ejfB-4hrwA:
undetectable		 2ejfB-4hrwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION
(Nitrosomonas
europaea) 		4 / 7 ARG A  72
ASN A  40
PRO A  10
ALA A  43
 None
 1.35A 2ejgA-4hrwA:
undetectable		 2ejgA-4hrwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION
(Nitrosomonas
europaea) 		4 / 5 PRO A  47
VAL A  37
THR A 163
GLY A 164
 None
 0.93A 3elzB-4hrwA:
undetectable		 3elzB-4hrwA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION
(Nitrosomonas
europaea) 		5 / 10 GLY A  46
PHE A  48
GLY A  71
ILE A  80
CYH A 115
 None
None
None
None
ZN  A 201 (-2.3A)
 1.40A 3ko0L-4hrwA:
undetectable
3ko0N-4hrwA:
undetectable		 3ko0L-4hrwA:
17.50
3ko0N-4hrwA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION
(Nitrosomonas
europaea) 		5 / 10 GLY A  71
ILE A  80
CYH A 115
GLY A  46
PHE A  48
 None
None
ZN  A 201 (-2.3A)
None
None
 1.40A 3ko0R-4hrwA:
undetectable
3ko0T-4hrwA:
undetectable		 3ko0R-4hrwA:
17.50
3ko0T-4hrwA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION
(Nitrosomonas
europaea) 		5 / 12 HIS A  77
ALA A 131
ASN A  40
PRO A  47
LEU A 174
 ZN  A 201 (-3.2A)
None
None
None
None
 1.30A 3tm4A-4hrwA:
undetectable		 3tm4A-4hrwA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION
(Nitrosomonas
europaea) 		5 / 12 HIS A  77
ALA A 131
ASN A  40
PRO A  47
LEU A 174
 ZN  A 201 (-3.2A)
None
None
None
None
 1.30A 3tm4B-4hrwA:
undetectable		 3tm4B-4hrwA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION
(Nitrosomonas
europaea) 		5 / 11 GLY A  31
LEU A  34
GLU A  35
LEU A  60
ALA A  63
 None
 1.17A 4wnuA-4hrwA:
undetectable		 4wnuA-4hrwA:
17.54