SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hs4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4hs4 CHROMATE REDUCTASE
(Komagataeibacter
hansenii) 		4 / 5 LEU A  29
PRO A  34
ALA A  33
ILE A  32
 None
 0.92A 2aofB-4hs4A:
undetectable		 2aofB-4hs4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4hs4 CHROMATE REDUCTASE
(Komagataeibacter
hansenii) 		5 / 12 LEU A 138
PHE A 137
GLN A  56
LEU A  92
VAL A  88
 None
 1.34A 2qd4B-4hs4A:
4.4		 2qd4B-4hs4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4hs4 CHROMATE REDUCTASE
(Komagataeibacter
hansenii) 		3 / 3 PRO A  34
PHE A   9
ALA A 181
 None
 0.63A 3itaD-4hs4A:
undetectable		 3itaD-4hs4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hs4 CHROMATE REDUCTASE
(Komagataeibacter
hansenii) 		4 / 7 ALA A  33
PRO A  34
ALA A 181
ARG A 185
 None
 1.01A 3twpA-4hs4A:
2.2		 3twpA-4hs4A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hs4 CHROMATE REDUCTASE
(Komagataeibacter
hansenii) 		4 / 7 ALA A  33
PRO A  34
ALA A 181
ARG A 185
 None
 1.04A 3twpB-4hs4A:
3.5		 3twpB-4hs4A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hs4 CHROMATE REDUCTASE
(Komagataeibacter
hansenii) 		4 / 7 ALA A  33
PRO A  34
ALA A 181
ARG A 185
 None
 1.05A 3twpC-4hs4A:
3.5		 3twpC-4hs4A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4hs4 CHROMATE REDUCTASE
(Komagataeibacter
hansenii) 		5 / 12 LEU A  65
ALA A  68
LEU A  12
ILE A  45
LEU A 138
 None
 1.11A 4dm8B-4hs4A:
undetectable		 4dm8B-4hs4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4hs4 CHROMATE REDUCTASE
(Komagataeibacter
hansenii) 		4 / 6 GLY A  90
SER A  15
THR A  81
VAL A  88
 None
 1.08A 5ysiA-4hs4A:
undetectable		 5ysiA-4hs4A:
22.05