SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S1U_A_NVPA999_1 (REVERSE TRANSCRIPTASE)	4hsb	PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2 (Schizosaccharomy ces pombe)	5 / 10	ILE A 197 VAL A 25 GLY A 29 LEU A 33 TYR A 7	None	0.98A	1s1uA-4hsbA: undetectable	1s1uA-4hsbA: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DTU_C_DXCC576_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2)	4hsb	PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2 (Schizosaccharomy ces pombe)	4 / 8	ALA A 107 ALA A 110 PRO A 79 ILE A 82	None	0.60A	3dtuC-4hsbA: undetectable 3dtuD-4hsbA: undetectable	3dtuC-4hsbA: 16.70 3dtuD-4hsbA: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB603_1 (PHIAB6 TAILSPIKE)	4hsb	PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2 (Schizosaccharomy ces pombe)	3 / 3	VAL A 184 GLU A 126 GLU A 145	None	0.76A	5jsdB-4hsbA: undetectable 5jsdC-4hsbA: undetectable	5jsdB-4hsbA: 13.59 5jsdC-4hsbA: 13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	4hsb	PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2 (Schizosaccharomy ces pombe)	3 / 3	MET A 130 ASP A 161 ARG A 195	None	1.22A	5z6kA-4hsbA: undetectable	5z6kA-4hsbA: 18.10

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1S1U_A_NVPA999_1","REVERSE TRANSCRIPTASE","4hsb","PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2","Schizosaccharomyces pombe",5,"ILE A 197;VAL A  25;GLY A  29;LEU A  33;TYR A   7","None","0.98A","1s1uA-4hsbA:undetectable","1s1uA-4hsbA:17.58"],["3DTU_C_DXCC576_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 2","4hsb","PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2","Schizosaccharomyces pombe",4,"ALA A 107;ALA A 110;PRO A  79;ILE A  82","None","0.60A","3dtuC-4hsbA:undetectable;3dtuD-4hsbA:undetectable","3dtuC-4hsbA:16.70;3dtuD-4hsbA:22.10"],["5JSD_B_1GNB603_1","PHIAB6 TAILSPIKE;PHIAB6 TAILSPIKE","4hsb","PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2","Schizosaccharomyces pombe",3,"VAL A 184;GLU A 126;GLU A 145","None","0.76A","5jsdB-4hsbA:undetectable;5jsdC-4hsbA:undetectable","5jsdB-4hsbA:13.59;5jsdC-4hsbA:13.59"],["5Z6K_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","4hsb","PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2","Schizosaccharomyces pombe",3,"MET A 130;ASP A 161;ARG A 195","None","1.22A","5z6kA-4hsbA:undetectable","5z6kA-4hsbA:18.10"]]