SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		3 / 3 GLU X 492
ILE X 494
ARG X 524
 None
 0.80A 1cd2A-4hscX:
undetectable		 1cd2A-4hscX:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 10 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.38A 1rqpA-4hscX:
0.0		 1rqpA-4hscX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 10 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.38A 1rqpB-4hscX:
undetectable		 1rqpB-4hscX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 10 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.33A 1rqpC-4hscX:
0.0		 1rqpC-4hscX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 9 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.36A 2v7uC-4hscX:
0.0		 2v7uC-4hscX:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 9 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.39A 2v7uA-4hscX:
0.0		 2v7uA-4hscX:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1300_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 9 ASP X 205
LEU X 206
THR X 303
TYR X 344
PHE X 422
 None
 1.37A 2v7uB-4hscX:
0.0		 2v7uB-4hscX:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 12 ILE X 557
ALA X 475
GLN X 476
TRP X 499
ILE X 568
 None
 1.00A 3e00A-4hscX:
undetectable		 3e00A-4hscX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 11 ILE X 557
ALA X 475
GLN X 476
TRP X 499
ILE X 568
 None
 0.94A 3fc6A-4hscX:
undetectable		 3fc6A-4hscX:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		3 / 3 LYS X 496
ARG X 498
LYS X 540
 None
 1.37A 3okxA-4hscX:
undetectable		 3okxA-4hscX:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 12 PRO X 430
ARG X 197
ILE X 202
VAL X 304
TYR X 344
 None
 1.36A 3p6gA-4hscX:
undetectable		 3p6gA-4hscX:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		3 / 3 GLY X 243
SER X 241
TRP X 236
 None
 0.91A 4e7cD-4hscX:
undetectable		 4e7cD-4hscX:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		4 / 6 LYS X 290
ILE X 285
VAL X 257
LYS X 351
 None
 1.06A 4em2A-4hscX:
undetectable		 4em2A-4hscX:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		4 / 8 THR X 347
LEU X 267
VAL X 269
VAL X 392
 None
 1.14A 4l4eA-4hscX:
undetectable		 4l4eA-4hscX:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		4 / 5 LEU X 278
ALA X 296
VAL X 415
ILE X 416
 None
 0.91A 4xe3B-4hscX:
undetectable		 4xe3B-4hscX:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		4 / 8 ILE X 465
LEU X 516
ILE X 479
ARG X 524
 None
 0.79A 4zvcA-4hscX:
undetectable
4zvcB-4hscX:
undetectable		 4zvcA-4hscX:
12.92
4zvcB-4hscX:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		4 / 8 ILE X 479
ARG X 524
ILE X 465
LEU X 516
 None
 0.81A 4zvcA-4hscX:
undetectable
4zvcB-4hscX:
undetectable		 4zvcA-4hscX:
12.92
4zvcB-4hscX:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		3 / 3 ALA X 228
ASN X 231
LEU X 232
 None
 0.39A 5i1oC-4hscX:
undetectable		 5i1oC-4hscX:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		3 / 3 ALA X 228
ASN X 231
LEU X 232
 None
 0.38A 5i1pA-4hscX:
undetectable		 5i1pA-4hscX:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 11 ASP X 317
SER X 319
VAL X 330
THR X 195
ILE X 113
 None
 1.25A 5y80A-4hscX:
undetectable		 5y80A-4hscX:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		5 / 12 ILE X 557
ALA X 475
GLN X 476
TRP X 499
ILE X 568
 None
 0.97A 6a5yD-4hscX:
undetectable		 6a5yD-4hscX:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4hsc STREPTOLYSIN O
(Streptococcus
pyogenes) 		4 / 5 ILE X 280
PHE X 282
ASN X 157
TYR X 452
 None
 1.15A 6a93B-4hscX:
undetectable		 6a93B-4hscX:
21.75