SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hse'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 4 LEU A 224
PRO A 221
LEU A 187
ARG A 188
 None
 1.42A 1hrkB-4hseA:
2.3		 1hrkB-4hseA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 4 LEU A 224
PRO A 221
LEU A 187
ARG A 188
 None
 1.45A 2hrcB-4hseA:
2.3		 2hrcB-4hseA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 4 LEU A 224
PRO A 221
LEU A 187
ARG A 188
 None
 1.33A 2pnjB-4hseA:
2.7		 2pnjB-4hseA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 5 LEU A 420
ARG A 417
ALA A 419
ILE A 435
 None
 1.11A 2qhfA-4hseA:
undetectable		 2qhfA-4hseA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 11 LEU A 211
VAL A 208
ILE A 215
GLU A 209
ALA A 212
 None
None
None
GAI  A 601 (-3.3A)
None
 1.15A 2yy8A-4hseA:
undetectable
2yy8B-4hseA:
undetectable		 2yy8A-4hseA:
21.37
2yy8B-4hseA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 4 VAL A 329
ASP A 270
LEU A 160
ARG A 175
 None
ADP  A 602 ( 4.8A)
None
None
 1.34A 2ziaA-4hseA:
undetectable		 2ziaA-4hseA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 10 VAL A 182
PHE A 268
ILE A 303
ALA A 206
VAL A 329
 None
None
None
ADP  A 602 (-3.6A)
None
 0.94A 3me6A-4hseA:
undetectable		 3me6A-4hseA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 9 VAL A 182
PHE A 268
ILE A 303
ALA A 206
VAL A 329
 None
None
None
ADP  A 602 (-3.6A)
None
 0.97A 3me6C-4hseA:
undetectable		 3me6C-4hseA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 9 VAL A 182
PHE A 268
ILE A 303
ALA A 206
VAL A 329
 None
None
None
ADP  A 602 (-3.6A)
None
 0.87A 3me6D-4hseA:
undetectable		 3me6D-4hseA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 5 ILE A 338
ARG A 370
THR A 366
GLU A 523
 None
 1.48A 3ny4A-4hseA:
undetectable		 3ny4A-4hseA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 7 VAL A 254
LEU A 251
LEU A 237
ILE A 269
 None
 0.99A 3u5kB-4hseA:
undetectable		 3u5kB-4hseA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 8 VAL A 254
LEU A 251
LEU A 237
ILE A 269
 None
 0.90A 3u5kC-4hseA:
undetectable		 3u5kC-4hseA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 5 VAL A 254
LEU A 251
LEU A 237
ILE A 269
 None
 0.98A 4a9jA-4hseA:
2.3		 4a9jA-4hseA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 12 VAL A 276
LEU A 237
LEU A 232
ILE A 255
LEU A 300
 None
 1.12A 4ky8E-4hseA:
undetectable		 4ky8E-4hseA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 12 LEU A 237
PHE A 247
ILE A 269
VAL A 275
VAL A 276
 None
 1.01A 4nkvA-4hseA:
undetectable		 4nkvA-4hseA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 11 ASP A 379
ILE A 382
ILE A 526
THR A 337
VAL A 334
 ADP  A 602 (-4.2A)
ADP  A 602 (-4.6A)
None
None
None
 0.99A 4qgiA-4hseA:
undetectable		 4qgiA-4hseA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 12 LEU A 291
PHE A 324
ILE A 314
GLY A 304
LEU A 232
 None
 1.16A 5fsaA-4hseA:
undetectable		 5fsaA-4hseA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 7 LEU A 302
THR A 306
THR A 307
LEU A 291
 None
 1.11A 5jq7B-4hseA:
undetectable		 5jq7B-4hseA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		5 / 12 LEU A 344
GLY A 203
THR A 205
VAL A 208
PHE A 268
 ADP  A 602 (-4.6A)
ADP  A 602 (-3.4A)
ADP  A 602 (-4.0A)
None
None
 1.15A 5x6yA-4hseA:
undetectable		 5x6yA-4hseA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4hse CHAPERONE PROTEIN
CLPB
(Thermus
thermophilus) 		4 / 7 VAL A 208
VAL A 327
PRO A 194
GLY A 304
 None
 0.97A 5x80C-4hseA:
2.2
5x80D-4hseA:
2.0		 5x80C-4hseA:
19.07
5x80D-4hseA:
19.07