SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.32A 3dqtA-4hsqA:
undetectable
3dqtB-4hsqA:
undetectable		 3dqtA-4hsqA:
18.58
3dqtB-4hsqA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 SER A 431
VAL A 442
ARG A 288
GLU A 441
 None
 1.35A 3n5tA-4hsqA:
undetectable
3n5tB-4hsqA:
undetectable		 3n5tA-4hsqA:
19.91
3n5tB-4hsqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		3 / 3 GLY A 277
SER A 276
TRP A 211
 None
 0.74A 4e7cD-4hsqA:
undetectable		 4e7cD-4hsqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.37A 4k5jA-4hsqA:
undetectable
4k5jB-4hsqA:
undetectable		 4k5jA-4hsqA:
19.91
4k5jB-4hsqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.24A 5adlA-4hsqA:
undetectable
5adlB-4hsqA:
undetectable		 5adlA-4hsqA:
19.91
5adlB-4hsqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.29A 5fj3A-4hsqA:
undetectable
5fj3B-4hsqA:
undetectable		 5fj3A-4hsqA:
19.91
5fj3B-4hsqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.30A 5vv7A-4hsqA:
undetectable
5vv7B-4hsqA:
undetectable		 5vv7A-4hsqA:
19.91
5vv7B-4hsqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.27A 5vvnA-4hsqA:
undetectable
5vvnB-4hsqA:
undetectable		 5vvnA-4hsqA:
19.91
5vvnB-4hsqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 SER A 431
VAL A 442
ARG A 288
GLU A 441
 None
 1.35A 6av6A-4hsqA:
undetectable
6av6B-4hsqA:
undetectable		 6av6A-4hsqA:
14.29
6av6B-4hsqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 SER A 431
VAL A 442
ARG A 288
GLU A 441
 None
 1.32A 6av7A-4hsqA:
undetectable
6av7B-4hsqA:
undetectable		 6av7A-4hsqA:
14.29
6av7B-4hsqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 4 VAL A 341
GLY A 377
ASP A 376
ASP A 375
 None
 1.32A 6cjkC-4hsqA:
4.5		 6cjkC-4hsqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4hsq PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 4 VAL A 445
GLY A 438
ASP A 440
ASP A 434
 None
 1.27A 6cjkC-4hsqA:
4.5		 6cjkC-4hsqA:
22.18