SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		3 / 3 LEU A 282
PHE A 284
ARG A 300
 None
 0.82A 1xdkF-4hssA:
undetectable		 1xdkF-4hssA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		5 / 11 LEU A  56
GLY A 127
GLY A 125
LEU A  54
SER A  53
 None
 0.85A 2qmmA-4hssA:
undetectable
2qmmB-4hssA:
undetectable		 2qmmA-4hssA:
19.30
2qmmB-4hssA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.43A 3dqtA-4hssA:
undetectable
3dqtB-4hssA:
undetectable		 3dqtA-4hssA:
23.90
3dqtB-4hssA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 SER A 431
VAL A 442
ARG A 288
GLU A 441
 None
 1.45A 3n5tA-4hssA:
undetectable
3n5tB-4hssA:
undetectable		 3n5tA-4hssA:
22.11
3n5tB-4hssA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 ILE A 304
GLU A 223
PHE A 222
VAL A 321
 None
 1.11A 4a97A-4hssA:
3.2		 4a97A-4hssA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		3 / 3 GLY A 277
SER A 276
TRP A 211
 None
 0.80A 4e7cD-4hssA:
undetectable		 4e7cD-4hssA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.47A 4k5jA-4hssA:
undetectable
4k5jB-4hssA:
undetectable		 4k5jA-4hssA:
22.11
4k5jB-4hssA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.37A 5adlA-4hssA:
undetectable
5adlB-4hssA:
undetectable		 5adlA-4hssA:
22.11
5adlB-4hssA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.39A 5fj3A-4hssA:
undetectable
5fj3B-4hssA:
undetectable		 5fj3A-4hssA:
22.11
5fj3B-4hssA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.43A 5vv7A-4hssA:
undetectable
5vv7B-4hssA:
undetectable		 5vv7A-4hssA:
22.11
5vv7B-4hssA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 GLU A 441
SER A 431
VAL A 442
ARG A 288
 None
 1.39A 5vvnA-4hssA:
undetectable
5vvnB-4hssA:
undetectable		 5vvnA-4hssA:
22.11
5vvnB-4hssA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 SER A 431
VAL A 442
ARG A 288
GLU A 441
 None
 1.45A 6av6A-4hssA:
undetectable
6av6B-4hssA:
undetectable		 6av6A-4hssA:
10.12
6av6B-4hssA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 7 SER A 431
VAL A 442
ARG A 288
GLU A 441
 None
 1.43A 6av7A-4hssA:
undetectable
6av7B-4hssA:
undetectable		 6av7A-4hssA:
10.12
6av7B-4hssA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4hss PUTATIVE FIMBRIAL
SUBUNIT
(Corynebacterium
diphtheriae) 		4 / 4 VAL A 341
GLY A 377
ASP A 376
ASP A 375
 None
 1.31A 6cjkC-4hssA:
5.7		 6cjkC-4hssA:
18.84