SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 7 TYR B  32
PHE B  31
VAL B  49
ILE B 176
 GLJ  B 601 (-4.9A)
None
None
None
 0.96A 11gsA-4hstB:
undetectable		 11gsA-4hstB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 6 ARG B 340
GLY B 449
ASP B 450
TYR B 467
 None
 1.16A 1kf6M-4hstB:
undetectable
1kf6N-4hstB:
undetectable		 1kf6M-4hstB:
21.65
1kf6N-4hstB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas;
Pseudomonas) 		5 / 12 TYR B  32
HIS B 178
ALA B 195
GLY A 162
ILE B  75
 GLJ  B 601 (-4.9A)
GLJ  B 601 (-4.0A)
None
None
None
 1.14A 1x1aA-4hstB:
undetectable		 1x1aA-4hstB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 5 ASP B 232
GLY B 183
VAL B 230
ILE B 231
 None
 0.99A 2aoiA-4hstB:
undetectable		 2aoiA-4hstB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas;
Pseudomonas) 		5 / 12 LEU A 142
LEU B 427
GLU A  86
GLY A  84
ASP B 113
 None
 1.13A 2bm9A-4hstA:
undetectable		 2bm9A-4hstA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas;
Pseudomonas) 		5 / 12 LEU A 142
LEU B 427
GLY A  84
ASP B 113
ALA A  80
 None
 1.01A 2bm9A-4hstA:
undetectable		 2bm9A-4hstA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		5 / 12 ASP B 509
CYH B 510
ASP B 288
ALA B 287
ALA B 283
 None
 1.02A 2br4C-4hstB:
undetectable		 2br4C-4hstB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		5 / 10 ALA B 402
ALA B 406
LEU B 410
LEU B 315
ALA B 335
 None
 1.10A 2bxeA-4hstB:
undetectable		 2bxeA-4hstB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		5 / 10 ALA B 338
PHE B 339
ALA B 402
LEU B 399
LEU B 410
 None
 1.13A 2bxqA-4hstB:
undetectable		 2bxqA-4hstB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 8 TYR B  32
PHE B  31
VAL B  49
ILE B 176
 GLJ  B 601 (-4.9A)
None
None
None
 0.88A 2gssA-4hstB:
undetectable		 2gssA-4hstB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 8 TYR B  32
PHE B  31
VAL B  49
ILE B 176
 GLJ  B 601 (-4.9A)
None
None
None
 0.88A 2gssB-4hstB:
undetectable		 2gssB-4hstB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		5 / 12 ARG A  64
ARG A  36
GLY B  46
LEU B 154
MET A 158
 None
 1.37A 2nyrB-4hstA:
undetectable		 2nyrB-4hstA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		3 / 3 ARG B 316
GLU B 302
GLN B 317
 None
 0.93A 2p16A-4hstB:
undetectable		 2p16A-4hstB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas;
Pseudomonas) 		5 / 12 MET A  99
LEU A 163
ILE B 106
SER B 141
VAL A 168
 None
 1.22A 2po7B-4hstA:
undetectable		 2po7B-4hstA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 7 THR B  13
VAL B   6
VAL B 474
ASP B 476
 None
 0.97A 2qbnA-4hstB:
undetectable		 2qbnA-4hstB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		3 / 3 SER B 492
TYR B 500
HIS B 499
 None
 0.76A 2r2vD-4hstB:
undetectable		 2r2vD-4hstB:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 8 MET B 515
ASP B 481
SER B 518
HIS B  60
 None
 1.22A 2v0gA-4hstB:
undetectable		 2v0gA-4hstB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
(Pseudomonas) 		4 / 8 VAL A  34
ARG A  54
GLY A 124
ALA A 127
 None
 0.89A 2xfsA-4hstA:
undetectable		 2xfsA-4hstA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
(Pseudomonas) 		4 / 8 VAL A  34
ARG A  54
GLY A 124
ALA A 127
 None
 0.88A 2xh9A-4hstA:
undetectable		 2xh9A-4hstA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		5 / 12 ILE B  17
ASP B 476
THR B  11
VAL B   6
ILE B 189
 None
 1.23A 2yzqA-4hstB:
undetectable		 2yzqA-4hstB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		5 / 12 MET A 158
THR A  71
GLY B  30
ARG A  64
LEU B  47
 None
 1.47A 3aobC-4hstA:
undetectable		 3aobC-4hstA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 7 TYR B  32
PHE B  31
VAL B  49
ILE B 176
 GLJ  B 601 (-4.9A)
None
None
None
 0.87A 3gssA-4hstB:
undetectable		 3gssA-4hstB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 7 TYR B  32
PHE B  31
VAL B  49
ILE B 176
 GLJ  B 601 (-4.9A)
None
None
None
 0.87A 3gssB-4hstB:
undetectable		 3gssB-4hstB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 8 TYR B  32
PHE B  31
VAL B  49
ILE B 176
 GLJ  B 601 (-4.9A)
None
None
None
 0.79A 3hjoA-4hstB:
undetectable		 3hjoA-4hstB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		5 / 10 ILE B 231
SER B 483
ALA B  19
LEU B  18
ALA B  65
 None
 1.42A 3lw5B-4hstB:
undetectable		 3lw5B-4hstB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 8 TYR B  32
PHE B  31
VAL B  49
ILE B 176
 GLJ  B 601 (-4.9A)
None
None
None
 0.93A 3n9jA-4hstB:
undetectable		 3n9jA-4hstB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 7 ASN B 242
ALA B 241
ARG B 472
ALA B 454
 GLJ  B 601 (-3.0A)
None
None
None
 1.02A 3twpB-4hstB:
undetectable		 3twpB-4hstB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 7 ASN B 242
ALA B 241
ARG B 472
ALA B 454
 GLJ  B 601 (-3.0A)
None
None
None
 1.00A 3twpC-4hstB:
undetectable		 3twpC-4hstB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
(Pseudomonas) 		5 / 12 ASP A 192
GLY A 194
GLY A 195
ARG A 190
ASP A 197
 None
 0.96A 3uboA-4hstA:
undetectable		 3uboA-4hstA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
(Pseudomonas) 		4 / 7 TYR A 121
GLU A  69
PRO A 136
TYR A 139
 None
 0.54A 3ugrA-4hstA:
undetectable		 3ugrA-4hstA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas;
Pseudomonas) 		4 / 5 ASP A 116
GLY A 111
VAL A 112
THR B 155
 None
 1.24A 3vqrB-4hstA:
undetectable		 3vqrB-4hstA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 6 THR B  69
ASN B   3
GLY B  20
ASP B  21
 None
 1.35A 3w9tE-4hstB:
undetectable		 3w9tE-4hstB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
(Pseudomonas) 		4 / 6 GLY A 143
TRP A  82
GLU A  69
ARG A  73
 None
 1.02A 4bqfA-4hstA:
undetectable		 4bqfA-4hstA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 6 ASN B   3
MET B 157
LEU B 192
ILE B 238
 None
 1.11A 4okxA-4hstB:
undetectable		 4okxA-4hstB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		5 / 10 TYR B 517
TRP B 480
LEU B 166
ALA B 169
GLY B 159
 None
 1.24A 4rn6A-4hstB:
undetectable		 4rn6A-4hstB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		3 / 3 VAL B 279
ALA B  19
PHE B 277
 None
 0.77A 4z4iA-4hstB:
undetectable		 4z4iA-4hstB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 5 VAL B 374
ILE A 201
PRO B 260
THR B  69
 None
 1.31A 4ze1A-4hstB:
undetectable		 4ze1A-4hstB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 5 ILE B 189
LEU B 166
HIS B  60
VAL B 477
 None
 1.19A 5jmnB-4hstB:
undetectable		 5jmnB-4hstB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		3 / 3 VAL B 279
ALA B  19
PHE B 277
 None
 0.73A 5js1A-4hstB:
undetectable		 5js1A-4hstB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 6 LEU B 290
SER B 291
ASP B 448
TRP B 322
 None
 1.20A 5om3A-4hstB:
undetectable
5om3B-4hstB:
undetectable		 5om3A-4hstB:
9.21
5om3B-4hstB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 7 VAL B 197
VAL B 193
ASP B 177
ALA B 195
 None
 0.60A 5osrA-4hstB:
undetectable		 5osrA-4hstB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 7 ARG B  88
VAL B 119
PRO B 131
GLY B  87
 None
 0.96A 5x80C-4hstB:
undetectable
5x80D-4hstB:
undetectable		 5x80C-4hstB:
15.10
5x80D-4hstB:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		3 / 3 ARG B 244
ARG A 174
ARG B 202
 None
 1.10A 6bplA-4hstB:
undetectable
6bplB-4hstB:
undetectable		 6bplA-4hstB:
9.96
6bplB-4hstB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas;
Pseudomonas) 		3 / 3 TYR A  53
ALA A  46
LEU B  37
 None
 0.74A 6d9kF-4hstA:
undetectable		 6d9kF-4hstA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
(Pseudomonas) 		4 / 6 TRP A 149
LEU A 161
TYR A 121
GLN A  62
 None
 1.47A 6djzC-4hstA:
undetectable		 6djzC-4hstA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 5 LEU B 399
LEU B 390
THR B 344
ARG A 190
 None
 1.01A 6ew0F-4hstB:
undetectable		 6ew0F-4hstB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 6 LEU B 399
LEU B 390
THR B 344
ARG A 190
 None
 1.01A 6ew0G-4hstB:
undetectable		 6ew0G-4hstB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
(Pseudomonas) 		4 / 4 ARG A  78
GLU A  81
GLU A 147
ARG A  73
 None
 1.17A 6fk2A-4hstA:
undetectable		 6fk2A-4hstA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas;
Pseudomonas) 		3 / 3 PHE A 170
ARG A 174
GLN B 373
 None
 1.05A 6g1pB-4hstA:
undetectable		 6g1pB-4hstA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		4 / 5 THR B 162
THR B 170
HIS B 224
GLY B 190
 None
 1.22A 6gbnC-4hstB:
undetectable		 6gbnC-4hstB:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN
(Pseudomonas) 		3 / 3 TRP B 101
ILE B 118
ASP B 117
 None
 0.64A 6i0y7-4hstB:
undetectable		 6i0y7-4hstB:
4.51