SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ht1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		5 / 12 TYR L  86
PHE L  62
VAL L  58
ASP L  82
ALA L  81
 None
 1.27A 1e3vA-4ht1L:
undetectable		 1e3vA-4ht1L:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4ht1 CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 6 TYR H 101
GLY H 100
ASP H 105
GLY T  33
 None
 0.97A 1eswA-4ht1H:
undetectable		 1eswA-4ht1H:
16.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		7 / 12 TYR L  36
GLN L  89
TYR H 103
PHE L 102
VAL H  37
ALA H  97
TRP H 110
 None
 1.27A 1h8sA-4ht1L:
20.2		 1h8sA-4ht1L:
37.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		4 / 7 LEU L 139
THR L 176
SER L 166
THR L 168
 None
 0.66A 1ictD-4ht1L:
undetectable		 1ictD-4ht1L:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		4 / 5 LEU L 183
GLY L 132
PRO L 124
VAL L 136
 None
 0.91A 2aojA-4ht1L:
undetectable		 2aojA-4ht1L:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		3 / 3 LYS H 208
GLY H 113
PRO H 112
 None
 0.96A 2hreB-4ht1H:
undetectable		 2hreB-4ht1H:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_L_CSCL1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		5 / 12 THR L 106
THR L  85
TYR L 144
GLN L 170
VAL L  19
 None
 1.39A 2vaxL-4ht1L:
0.0		 2vaxL-4ht1L:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4ht1 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12
(Homo
sapiens) 		5 / 11 LEU T 121
SER T 127
PHE T 148
VAL T 117
LEU T  84
 None
 1.14A 3a9eB-4ht1T:
undetectable		 3a9eB-4ht1T:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4ht1 CHIMERIC ANTIBODY
FAB
CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Homo
sapiens) 		4 / 5 ASN L  32
ASP T  32
GLU T  57
THR H  31
 None
 1.42A 3p2kC-4ht1L:
undetectable		 3p2kC-4ht1L:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_1
(16S RRNA METHYLASE)		 4ht1 CHIMERIC ANTIBODY
FAB
CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Homo
sapiens) 		4 / 4 ASN L  32
ASP T  32
GLU T  57
THR H  31
 None
 1.39A 3p2kD-4ht1L:
0.0		 3p2kD-4ht1L:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		3 / 3 TYR L  93
ARG L  96
SER L  95
 None
 1.15A 4dr2I-4ht1L:
undetectable
4dr2J-4ht1L:
undetectable		 4dr2I-4ht1L:
23.66
4dr2J-4ht1L:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		5 / 11 VAL H 118
ALA H  92
PHE H  68
SER H  85
VAL H  12
 None
 1.47A 4eilE-4ht1H:
undetectable		 4eilE-4ht1H:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		5 / 10 PHE H 129
GLY H 125
THR H 212
VAL H 205
VAL H 214
 None
 1.17A 4jx1B-4ht1H:
undetectable		 4jx1B-4ht1H:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		5 / 12 GLY L 132
LEU L 185
SER L 135
ASP L 189
ALA L 188
 None
 0.99A 4krhA-4ht1L:
undetectable		 4krhA-4ht1L:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		3 / 3 TYR L  93
ARG L  96
SER L  95
 None
 1.19A 4lf7I-4ht1L:
undetectable
4lf7J-4ht1L:
undetectable		 4lf7I-4ht1L:
23.66
4lf7J-4ht1L:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		3 / 3 TYR L  93
ARG L  96
SER L  95
 None
 1.19A 4lf8I-4ht1L:
undetectable
4lf8J-4ht1L:
undetectable		 4lf8I-4ht1L:
23.66
4lf8J-4ht1L:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		4 / 6 ASP L 174
THR L 176
TYR L 144
THR L 113
 None
 1.27A 5b6iB-4ht1L:
undetectable		 5b6iB-4ht1L:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4ht1 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12
(Homo
sapiens) 		5 / 9 LEU T 120
LEU T  65
ALA T  93
VAL T  88
ALA T 122
 None
 1.47A 5g44A-4ht1T:
undetectable		 5g44A-4ht1T:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		5 / 12 PRO L   8
VAL L 108
ALA L  14
ALA L  13
VAL L  19
 None
 1.28A 5igpA-4ht1L:
undetectable		 5igpA-4ht1L:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		4 / 5 PHE H  68
ILE H  48
MET H  83
ARG H  67
 None
 1.11A 5jm4A-4ht1H:
undetectable		 5jm4A-4ht1H:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4ht1 CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12
(Homo
sapiens;
Oryctolagus
cuniculus) 		5 / 12 SER L  52
LYS L  63
GLN T  28
GLU T  76
LEU T 134
 None
 1.24A 5nwwA-4ht1L:
undetectable		 5nwwA-4ht1L:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4ht1 CHIMERIC ANTIBODY
FAB
(Oryctolagus
cuniculus) 		4 / 7 PHE L 102
ALA H  97
GLY H  99
TYR H  33
 None
 0.93A 5uxdA-4ht1L:
undetectable		 5uxdA-4ht1L:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4ht1 CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12
(Oryctolagus
cuniculus;
Homo
sapiens) 		3 / 3 ASP T  85
LEU T  87
ARG L  96
 None
 0.89A 7dfrA-4ht1T:
undetectable		 7dfrA-4ht1T:
17.86