SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ht4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 4ht4 NICKING ENZYME
(Staphylococcus
aureus) 		3 / 3 TRP A 169
ARG A 170
PHE A   6
 None
 1.48A 1zeaH-4ht4A:
2.1
1zeaL-4ht4A:
undetectable		 1zeaH-4ht4A:
21.89
1zeaL-4ht4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4ht4 NICKING ENZYME
(Staphylococcus
aureus) 		5 / 12 SER A  29
SER A  27
SER A  50
THR A 137
VAL A  72
 None
None
CA  A 202 ( 4.9A)
None
None
 1.15A 2nniA-4ht4A:
undetectable		 2nniA-4ht4A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4ht4 NICKING ENZYME
(Staphylococcus
aureus) 		3 / 3 LYS A  22
LEU A 135
ALA A  19
 None
 0.82A 4iizA-4ht4A:
undetectable		 4iizA-4ht4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4ht4 NICKING ENZYME
(Staphylococcus
aureus) 		4 / 8 ALA A 108
ILE A  89
ILE A  87
GLU A  86
 None
 0.70A 5mvmA-4ht4A:
1.5
5mvmB-4ht4A:
1.7		 5mvmA-4ht4A:
19.21
5mvmB-4ht4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4ht4 NICKING ENZYME
(Staphylococcus
aureus) 		3 / 3 ASP A  64
SER A  23
SER A  27
 None
 0.57A 6mxtA-4ht4A:
undetectable		 6mxtA-4ht4A:
17.47