SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hte'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4hte NICKING ENZYME
(Staphylococcus
aureus) 		4 / 6 SER A 402
SER A 565
GLN A 553
ASP A 397
 None
 1.32A 2zvjA-4hteA:
undetectable		 2zvjA-4hteA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hte NICKING ENZYME
(Staphylococcus
aureus) 		5 / 12 ASN A 362
THR A 281
VAL A 280
LEU A 255
GLN A 332
 None
 1.42A 3elzC-4hteA:
undetectable		 3elzC-4hteA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4hte NICKING ENZYME
(Staphylococcus
aureus) 		5 / 11 ASP A 397
ALA A 455
TYR A 462
GLY A 394
SER A 402
 None
 1.26A 4xnxA-4hteA:
undetectable		 4xnxA-4hteA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFT_A_51GA204_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE (2')-IA)		 4hte NICKING ENZYME
(Staphylococcus
aureus) 		5 / 9 ASP A 569
ASP A 566
LEU A 557
ASP A 563
ASP A 397
 CA  A 601 ( 3.7A)
None
None
None
None
 1.02A 5cftA-4hteA:
2.2		 5cftA-4hteA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hte NICKING ENZYME
(Staphylococcus
aureus) 		3 / 3 TYR A 517
ARG A 522
THR A 526
 None
 0.94A 5z84J-4hteA:
undetectable		 5z84J-4hteA:
11.54