SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4htg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 199
ALA A 178
LEU A 183
GLN A 210
ARG A 142
 None
None
None
ACT  A 402 ( 4.9A)
18W  A 401 (-3.8A)
 1.26A 1kt6A-4htgA:
undetectable		 1kt6A-4htgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 THR A 236
ALA A 239
ARG A 112
PRO A 111
 None
 1.40A 2ql8A-4htgA:
undetectable
2ql8B-4htgA:
undetectable		 2ql8A-4htgA:
18.51
2ql8B-4htgA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ARG A 188
ALA A 184
ASP A 114
GLU A 113
 None
 1.36A 2xrzA-4htgA:
undetectable		 2xrzA-4htgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ASP A 221
ARG A  14
ILE A  13
VAL A  90
 None
 1.24A 3eigA-4htgA:
undetectable		 3eigA-4htgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A  15
LEU A  34
GLY A 214
THR A  30
LEU A 231
 None
 0.94A 3uq6A-4htgA:
undetectable		 3uq6A-4htgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A  15
LEU A  34
GLY A 214
THR A  30
LEU A 231
 None
 0.87A 3uq6B-4htgA:
undetectable		 3uq6B-4htgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A  15
LEU A  34
GLY A 214
THR A  30
LEU A 231
 None
 0.94A 3vaqA-4htgA:
undetectable		 3vaqA-4htgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A  15
LEU A  34
GLY A 214
THR A  30
LEU A 231
 None
 0.99A 3vaqB-4htgA:
undetectable		 3vaqB-4htgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A  15
LEU A  34
GLY A 214
THR A  30
LEU A 231
 None
 0.96A 3vasA-4htgA:
undetectable		 3vasA-4htgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 PHE A 272
ALA A 305
ALA A 245
THR A 249
 None
 0.74A 4dtzA-4htgA:
undetectable		 4dtzA-4htgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 PHE A 272
ALA A 305
ALA A 245
THR A 249
 None
 0.73A 4dtzB-4htgA:
undetectable		 4dtzB-4htgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 PHE A 272
ALA A 305
ALA A 245
THR A 249
 None
 0.67A 4du2A-4htgA:
undetectable		 4du2A-4htgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 PHE A 272
ALA A 305
ALA A 245
THR A 249
 None
 0.75A 4du2B-4htgA:
undetectable		 4du2B-4htgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLU A 234
LEU A 228
GLY A 214
ALA A 216
ILE A 105
 None
 1.25A 4xe5A-4htgA:
undetectable		 4xe5A-4htgA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A 140
GLY A 211
GLU A 113
ARG A 142
 18W  A 401 (-2.5A)
None
None
18W  A 401 (-3.8A)
 1.09A 5cdqR-4htgA:
undetectable
5cdqS-4htgA:
undetectable
5cdqT-4htgA:
undetectable		 5cdqR-4htgA:
22.07
5cdqS-4htgA:
22.97
5cdqT-4htgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLY A 211
ARG A 143
GLN A 146
ASP A 117
 None
ACT  A 402 ( 2.6A)
None
None
 0.87A 5vlmA-4htgA:
undetectable		 5vlmA-4htgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLY A 211
ARG A 143
GLN A 146
VAL A 115
 None
ACT  A 402 ( 2.6A)
None
None
 1.00A 5vlmA-4htgA:
undetectable		 5vlmA-4htgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLY A 211
ARG A 143
GLN A 146
ASP A 117
 None
ACT  A 402 ( 2.6A)
None
None
 0.84A 5vlmB-4htgA:
undetectable		 5vlmB-4htgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A  81
GLY A  84
ARG A 218
ARG A  14
 None
 0.82A 6gtqB-4htgA:
undetectable
6gtqD-4htgA:
undetectable		 6gtqB-4htgA:
22.71
6gtqD-4htgA:
11.11