SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIM_A_CELA711_1 (LACTOTRANSFERRIN)	4hti	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 (Homo sapiens)	5 / 9	GLU A 525 GLY A 526 VAL A 549 GLU A 571 GLY A 512	None	1.35A	4fimA-4htiA: undetectable	4fimA-4htiA: 15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_A_ACTA502_0 (RNA POLYMERASE 3D-POL)	4hti	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 (Homo sapiens)	3 / 3	ARG A 511 LYS A 510 LYS A 557	None	1.27A	4k50A-4htiA: undetectable	4k50A-4htiA: 11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_E_ACTE502_0 (RNA POLYMERASE 3D-POL)	4hti	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 (Homo sapiens)	3 / 3	ARG A 511 LYS A 510 LYS A 557	None	1.22A	4k50E-4htiA: undetectable	4k50E-4htiA: 11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI506_0 (RNA POLYMERASE 3D-POL)	4hti	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 (Homo sapiens)	3 / 3	ARG A 511 LYS A 510 LYS A 557	None	1.28A	4k50I-4htiA: 3.8	4k50I-4htiA: 11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZJ_A_TEPA2401_1 (ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A)	4hti	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 (Homo sapiens)	4 / 8	LEU A 536 GLU A 582 LEU A 529 ILE A 514	None	1.02A	5mzjA-4htiA: undetectable	5mzjA-4htiA: 13.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4FIM_A_CELA711_1","LACTOTRANSFERRIN","4hti","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2","Homo sapiens",5,"GLU A 525;GLY A 526;VAL A 549;GLU A 571;GLY A 512","None","1.35A","4fimA-4htiA:undetectable","4fimA-4htiA:15.82"],["4K50_A_ACTA502_0","RNA POLYMERASE 3D-POL","4hti","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2","Homo sapiens",3,"ARG A 511;LYS A 510;LYS A 557","None","1.27A","4k50A-4htiA:undetectable","4k50A-4htiA:11.55"],["4K50_E_ACTE502_0","RNA POLYMERASE 3D-POL","4hti","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2","Homo sapiens",3,"ARG A 511;LYS A 510;LYS A 557","None","1.22A","4k50E-4htiA:undetectable","4k50E-4htiA:11.55"],["4K50_I_ACTI506_0","RNA POLYMERASE 3D-POL","4hti","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2","Homo sapiens",3,"ARG A 511;LYS A 510;LYS A 557","None","1.28A","4k50I-4htiA:3.8","4k50I-4htiA:11.55"],["5MZJ_A_TEPA2401_1","ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A","4hti","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2","Homo sapiens",4,"LEU A 536;GLU A 582;LEU A 529;ILE A 514","None","1.02A","5mzjA-4htiA:undetectable","5mzjA-4htiA:13.38"]]