SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4htp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4htp DNA LIGASE 4
(Homo
sapiens) 		5 / 12 LEU A 152
LEU A 221
ILE A 203
LEU A 194
LEU A 186
 None
 1.03A 1errB-4htpA:
undetectable		 1errB-4htpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4htp DNA LIGASE 4
(Homo
sapiens) 		3 / 3 PRO A  66
ASN A 149
ARG A  79
 None
 0.78A 2qeuB-4htpA:
undetectable		 2qeuB-4htpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4htp DNA LIGASE 4
(Homo
sapiens) 		5 / 12 LEU A 152
LEU A 186
GLN A 183
ILE A  84
LEU A  89
 None
 1.18A 3datA-4htpA:
undetectable		 3datA-4htpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4htp DNA LIGASE 4
(Homo
sapiens) 		4 / 8 PRO A  66
SER A  63
LEU A 221
ASP A 220
 None
 1.08A 3lsfH-4htpA:
undetectable		 3lsfH-4htpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4htp DNA LIGASE 4
(Homo
sapiens) 		4 / 7 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.10A 3lslA-4htpA:
undetectable
3lslD-4htpA:
undetectable		 3lslA-4htpA:
20.38
3lslD-4htpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4htp DNA LIGASE 4
(Homo
sapiens) 		4 / 7 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.15A 3lslA-4htpA:
undetectable
3lslD-4htpA:
undetectable		 3lslA-4htpA:
20.38
3lslD-4htpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4htp DNA LIGASE 4
(Homo
sapiens) 		4 / 6 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.14A 3lslG-4htpA:
undetectable		 3lslG-4htpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4htp DNA LIGASE 4
(Homo
sapiens) 		5 / 12 LEU A 152
LEU A 186
ILE A  84
LEU A  89
ILE A 191
 None
 1.03A 3tq9A-4htpA:
undetectable		 3tq9A-4htpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4htp DNA LIGASE 4
(Homo
sapiens) 		6 / 11 CYH A 225
LEU A  75
LEU A 221
SER A  63
LEU A 196
ILE A 203
 None
 1.47A 4dm8A-4htpA:
undetectable		 4dm8A-4htpA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 4htp DNA LIGASE 4
(Homo
sapiens) 		3 / 3 VAL A 198
SER A 199
THR A 202
 None
 0.47A 4luhA-4htpA:
undetectable		 4luhA-4htpA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4htp DNA LIGASE 4
(Homo
sapiens) 		3 / 3 ASP A 210
ARG A  40
ARG A  47
 None
 0.93A 4x5iA-4htpA:
undetectable		 4x5iA-4htpA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4htp DNA LIGASE 4
(Homo
sapiens) 		4 / 4 VAL A  10
ALA A  11
ASN A 149
GLN A 146
 None
 1.29A 4zgfA-4htpA:
undetectable		 4zgfA-4htpA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4htp DNA LIGASE 4
(Homo
sapiens) 		5 / 12 SER A  63
TRP A  46
THR A 144
ALA A  67
ASN A 149
 None
 1.46A 5dsgA-4htpA:
undetectable		 5dsgA-4htpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4htp DNA LIGASE 4
(Homo
sapiens) 		5 / 12 SER A  63
TRP A  46
THR A 144
ALA A  67
ASN A 149
 None
 1.45A 5dsgB-4htpA:
undetectable		 5dsgB-4htpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4htp DNA LIGASE 4
(Homo
sapiens) 		3 / 3 ASP A 210
ARG A  40
ARG A  47
 None
 0.88A 5eajB-4htpA:
undetectable		 5eajB-4htpA:
20.00