SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 11 GLY A  26
ALA A  28
PHE A  29
ALA A  32
LEU A  64
 None
 1.11A 1ukbA-4htsA:
undetectable		 1ukbA-4htsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 12 PHE A  29
GLY A  26
GLY A  24
ILE A  67
ALA A  32
 None
 0.98A 1v2xA-4htsA:
undetectable		 1v2xA-4htsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 12 ALA A  70
ILE A  67
ILE A 162
GLU A 165
PHE A  21
 None
 1.24A 3axtA-4htsA:
undetectable		 3axtA-4htsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 12 ALA A 203
LEU A 130
ILE A  43
PRO A  42
SER A  46
 None
 1.17A 3nrrA-4htsA:
undetectable		 3nrrA-4htsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 12 GLY A  24
ALA A  28
ILE A  23
LEU A  69
ILE A  80
 None
 0.90A 4azvA-4htsA:
undetectable		 4azvA-4htsA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		4 / 8 SER A 107
ILE A 168
TRP A  85
PHE A  84
 None
 1.22A 4cx7C-4htsA:
undetectable
4cx7D-4htsA:
0.9		 4cx7C-4htsA:
23.27
4cx7D-4htsA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 12 PHE A  36
LEU A  39
ALA A  40
LEU A  52
ILE A  53
 None
 1.06A 4dm8B-4htsA:
undetectable		 4dm8B-4htsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 12 ALA A 126
PHE A 129
THR A 208
PHE A 152
LEU A 156
 None
 1.06A 5k9dA-4htsA:
undetectable		 5k9dA-4htsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 11 GLY A 199
LEU A 216
ALA A 163
ALA A 159
PHE A 160
 None
 1.31A 6qgbA-4htsA:
undetectable		 6qgbA-4htsA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4hts SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC
(Aquifex
aeolicus) 		5 / 11 GLY A 199
LEU A 216
ALA A 163
ALA A 159
PHE A 160
 None
 1.33A 6qgbE-4htsA:
undetectable		 6qgbE-4htsA:
17.24