SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4htt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Aquifex
aeolicus;
Escherichia
virus
T4) 		4 / 5 GLU A 221
LEU A 216
LEU A 217
LEU A 219
 None
 1.01A 1np1A-4httA:
undetectable		 1np1A-4httA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Escherichia
virus
T4;
Aquifex
aeolicus) 		6 / 11 GLY A  26
ALA A  28
PHE A  29
ALA A  32
LEU A  64
VAL A  71
 None
 1.05A 1ukbA-4httA:
undetectable		 1ukbA-4httA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Escherichia
virus
T4;
Aquifex
aeolicus) 		5 / 11 GLY A 161
ALA A 163
PHE A 164
PHE A 191
LEU A 219
 None
 1.09A 1ukbA-4httA:
undetectable		 1ukbA-4httA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Aquifex
aeolicus;
Escherichia
virus
T4) 		4 / 7 ALA A 115
GLY A 161
PHE A  73
PHE A  21
 None
 0.99A 2wq5A-4httA:
undetectable		 2wq5A-4httA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Aquifex
aeolicus;
Escherichia
virus
T4) 		4 / 7 LEU A  52
ILE A 150
ALA A 115
ILE A  74
 None
 0.69A 2xkwA-4httA:
undetectable		 2xkwA-4httA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Escherichia
virus
T4;
Aquifex
aeolicus) 		5 / 12 ILE A 162
GLY A 161
VAL A 158
ILE A  74
LEU A 110
 None
 1.01A 3fpjA-4httA:
undetectable		 3fpjA-4httA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Aquifex
aeolicus;
Escherichia
virus
T4) 		5 / 11 PRO A  42
VAL A  71
ALA A  70
PHE A 152
ILE A  67
 None
 1.28A 3n23A-4httA:
undetectable		 3n23A-4httA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Escherichia
virus
T4;
Aquifex
aeolicus) 		5 / 12 LEU A 170
TYR A 220
ILE A 179
VAL A 197
PHE A 191
 None
 1.25A 3vw1D-4httA:
2.7		 3vw1D-4httA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Escherichia
virus
T4;
Aquifex
aeolicus) 		5 / 12 GLY A  24
ALA A  28
ILE A  23
LEU A  69
ILE A  80
 None
 0.94A 4azvA-4httA:
undetectable		 4azvA-4httA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME
(Aquifex
aeolicus;
Escherichia
virus
T4) 		5 / 11 GLU A 165
ILE A 162
LEU A 216
GLY A 114
PHE A 111
 None
 1.37A 4foxF-4httA:
undetectable		 4foxF-4httA:
22.14