SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4htz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 ILE A 870
ALA A 767
LEU A 689
ILE A 764
PHE A 878
None
1.14A 1bsxA-4htzA:
1.9
1bsxA-4htzA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 ILE A 870
ALA A 767
LEU A 689
ILE A 764
PHE A 878
None
1.15A 1bsxB-4htzA:
1.8
1bsxB-4htzA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 6 LEU A 809
LEU A 802
HIS A 696
LEU A 677
None
None
ZN  A1001 (-3.4A)
None
0.88A 1errA-4htzA:
undetectable
1errA-4htzA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 TYR A 655
LEU A 770
LEU A 809
GLN A 859
PHE A 862
None
0.53A 1tbfA-4htzA:
43.8
1tbfA-4htzA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 11 TYR A 655
ILE A 822
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.68A 1uduA-4htzA:
39.1
1uduA-4htzA:
35.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
ILE A 822
PHE A 830
GLN A 859
PHE A 862
None
0.68A 1uduB-4htzA:
39.1
1uduB-4htzA:
35.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 10 TYR A 655
HIS A 656
PHE A 830
GLN A 859
PHE A 862
None
0.21A 1uhoA-4htzA:
40.8
1uhoA-4htzA:
35.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 6 MET A 694
LEU A 738
PHE A 746
MET A 761
None
1.13A 1x8vA-4htzA:
undetectable
1x8vA-4htzA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
HIS A 700
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
0.67A 1xlxA-4htzA:
38.7
1xlxA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
HIS A 700
ILE A 826
PHE A 830
GLN A 859
PHE A 862
None
0.42A 1xlxB-4htzA:
38.6
1xlxB-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
ILE A 826
MET A 847
GLN A 859
PHE A 862
None
0.89A 1xlxB-4htzA:
38.6
1xlxB-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 830
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
None
0.64A 1xmuA-4htzA:
38.7
1xmuA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 830
None
None
ZN  A1001 (-2.5A)
None
None
None
0.54A 1xmuB-4htzA:
38.8
1xmuB-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
ASP A 697
ILE A 826
PHE A 830
MET A 847
None
MG  A1002 ( 2.6A)
None
None
None
1.29A 1xomA-4htzA:
38.6
1xomA-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
8 / 12 TYR A 655
ASP A 808
LEU A 809
ILE A 826
PHE A 830
MET A 847
GLN A 859
PHE A 862
None
ZN  A1001 (-2.5A)
None
None
None
None
None
None
0.97A 1xomA-4htzA:
38.6
1xomA-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
8 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 830
GLN A 859
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
None
None
0.67A 1xomA-4htzA:
38.6
1xomA-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
LEU A 809
ILE A 826
PHE A 830
GLN A 859
PHE A 862
None
0.67A 1xomB-4htzA:
38.9
1xomB-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
LEU A 809
ILE A 826
PHE A 830
MET A 847
GLN A 859
PHE A 862
None
0.92A 1xomB-4htzA:
38.9
1xomB-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
0.64A 1xoqA-4htzA:
38.6
1xoqA-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
0.66A 1xoqB-4htzA:
38.8
1xoqB-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
LEU A 809
ILE A 826
MET A 847
PHE A 862
None
1.11A 1xoqB-4htzA:
38.8
1xoqB-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
ASP A 808
LEU A 809
MET A 847
GLN A 859
PHE A 862
ILE A 866
None
ZN  A1001 (-2.5A)
None
None
None
None
None
0.90A 1xosA-4htzA:
38.8
1xosA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
8 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
PHE A 830
GLN A 859
PHE A 862
ILE A 866
None
None
ZN  A1001 (-2.5A)
None
None
None
None
None
0.60A 1xosA-4htzA:
38.8
1xosA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
HIS A 660
GLN A 859
PHE A 862
ILE A 866
None
ZN  A1001 (-3.4A)
None
None
None
1.38A 1xosA-4htzA:
38.8
1xosA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
LEU A 809
ILE A 826
GLN A 859
PHE A 862
ILE A 866
None
0.50A 1xotA-4htzA:
38.8
1xotA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
LEU A 809
ILE A 826
MET A 847
GLN A 859
PHE A 862
ILE A 866
None
0.82A 1xotA-4htzA:
38.8
1xotA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
LEU A 809
ILE A 826
MET A 847
GLN A 859
PHE A 862
None
0.76A 1xotB-4htzA:
38.9
1xotB-4htzA:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
ILE A 822
PHE A 830
ILE A 855
GLN A 859
None
0.73A 1xozA-4htzA:
43.9
1xozA-4htzA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.40A 1xozA-4htzA:
43.9
1xozA-4htzA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 6 ARG A 728
SER A 724
ARG A 762
GLU A 727
None
1.07A 2c8aC-4htzA:
undetectable
2c8aC-4htzA:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 11 TYR A 655
HIS A 656
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.45A 2h42A-4htzA:
40.3
2h42A-4htzA:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
HIS A 656
ILE A 855
GLN A 859
PHE A 862
None
0.42A 2h42B-4htzA:
40.3
2h42B-4htzA:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
LEU A 770
LEU A 809
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.57A 2h42C-4htzA:
40.1
2h42C-4htzA:
35.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ASP A 808
ASP A 697
HIS A 660
SER A 665
ZN  A1001 (-2.5A)
MG  A1002 ( 2.6A)
ZN  A1001 (-3.4A)
None
1.09A 2q0iA-4htzA:
undetectable
2q0iA-4htzA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 10 ASP A 808
HIS A 656
ASP A 697
GLU A 727
LEU A 770
ZN  A1001 (-2.5A)
None
MG  A1002 ( 2.6A)
None
None
1.21A 2q0jA-4htzA:
undetectable
2q0jA-4htzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 ASP A 808
HIS A 656
ASP A 697
GLU A 727
LEU A 770
ZN  A1001 (-2.5A)
None
MG  A1002 ( 2.6A)
None
None
1.23A 2q0jB-4htzA:
undetectable
2q0jB-4htzA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
11 / 12 TYR A 655
HIS A 656
LEU A 770
LEU A 809
ILE A 826
TYR A 827
GLU A 829
PHE A 830
MET A 847
GLN A 859
PHE A 862
None
0.65A 2weyA-4htzA:
41.2
2weyA-4htzA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 LEU A 623
VAL A 646
PHE A 746
MET A 757
None
0.89A 2weyB-4htzA:
40.9
2weyB-4htzA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 8 LEU A 770
ILE A 826
TYR A 827
PHE A 830
MET A 847
GLN A 859
PHE A 862
None
0.68A 2weyB-4htzA:
40.9
2weyB-4htzA:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
LEU A 809
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.61A 3b2rA-4htzA:
35.8
3b2rA-4htzA:
35.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 11 TYR A 655
HIS A 656
LEU A 809
ILE A 855
GLN A 859
PHE A 862
None
0.61A 3b2rB-4htzA:
35.7
3b2rB-4htzA:
35.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
3 / 3 ASP A 808
LEU A 809
GLN A 859
ZN  A1001 (-2.5A)
None
None
0.45A 3g4lA-4htzA:
38.5
3g4lA-4htzA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
0.58A 3g4lB-4htzA:
38.6
3g4lB-4htzA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
LEU A 809
ILE A 826
MET A 847
PHE A 862
None
0.99A 3g4lB-4htzA:
38.6
3g4lB-4htzA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
None
None
ZN  A1001 (-2.5A)
None
None
0.52A 3g4lC-4htzA:
38.5
3g4lC-4htzA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
GLN A 859
None
None
ZN  A1001 (-2.5A)
None
None
None
0.60A 3g4lD-4htzA:
38.8
3g4lD-4htzA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 708
GLU A 727
THR A 768
HIS A 696
None
None
MG  A1002 ( 4.7A)
ZN  A1001 (-3.4A)
1.38A 3glqB-4htzA:
undetectable
3glqB-4htzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 9 TYR A 655
ILE A 826
PHE A 830
GLN A 859
PHE A 862
ILE A 866
None
0.43A 3iakA-4htzA:
38.1
3iakA-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 9 TYR A 655
ILE A 826
PHE A 830
MET A 847
PHE A 862
ILE A 866
None
0.85A 3iakA-4htzA:
38.1
3iakA-4htzA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 9 TYR A 655
HIS A 656
LEU A 770
MET A 847
GLN A 859
PHE A 862
None
0.39A 3jwqA-4htzA:
44.3
3jwqA-4htzA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 11 TYR A 655
HIS A 656
ASN A 704
LEU A 770
MET A 847
GLN A 859
PHE A 862
None
0.80A 3jwqB-4htzA:
44.1
3jwqC-4htzA:
44.2
3jwqB-4htzA:
35.54
3jwqC-4htzA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 7 TYR A 655
HIS A 656
MET A 847
GLN A 859
PHE A 862
None
0.42A 3jwqC-4htzA:
44.2
3jwqC-4htzA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 11 TYR A 655
HIS A 656
LEU A 770
PHE A 830
MET A 847
GLN A 859
PHE A 862
None
0.66A 3jwqA-4htzA:
44.3
3jwqD-4htzA:
43.9
3jwqA-4htzA:
35.54
3jwqD-4htzA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 TYR A 655
HIS A 656
LEU A 770
PHE A 830
MET A 848
None
1.28A 3jwqA-4htzA:
44.3
3jwqD-4htzA:
43.9
3jwqA-4htzA:
35.54
3jwqD-4htzA:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 GLU A 893
ASN A 891
MET A 863
ILE A 860
None
1.16A 3kp6A-4htzA:
undetectable
3kp6B-4htzA:
undetectable
3kp6A-4htzA:
19.71
3kp6B-4htzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 708
GLU A 727
THR A 768
HIS A 696
None
None
MG  A1002 ( 4.7A)
ZN  A1001 (-3.4A)
1.32A 3n58A-4htzA:
undetectable
3n58A-4htzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 TYR A 655
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
0.54A 3tvxA-4htzA:
39.0
3tvxA-4htzA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 TYR A 655
LEU A 809
ILE A 826
MET A 847
PHE A 862
None
0.91A 3tvxA-4htzA:
39.0
3tvxA-4htzA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 7 TYR A 655
ILE A 826
PHE A 830
MET A 847
GLN A 859
PHE A 862
None
0.82A 3tvxB-4htzA:
38.9
3tvxB-4htzA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 875
THR A 805
HIS A 773
LEU A 780
None
1.25A 4lvcA-4htzA:
undetectable
4lvcA-4htzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 875
THR A 805
HIS A 773
LEU A 780
None
1.26A 4lvcC-4htzA:
undetectable
4lvcC-4htzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 4 LEU A 884
SER A 810
LEU A 670
LEU A 874
None
1.06A 4n09A-4htzA:
undetectable
4n09A-4htzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 LEU A 639
ILE A 619
ILE A 634
ILE A 691
PHE A 687
None
1.05A 4rp8C-4htzA:
2.1
4rp8C-4htzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 TYR A 669
ASP A 625
PHE A 600
ILE A 619
ILE A 629
None
1.23A 5hw8D-4htzA:
undetectable
5hw8D-4htzA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 TYR A 669
ASP A 625
PHE A 600
ILE A 619
ILE A 590
None
1.19A 5hw8G-4htzA:
undetectable
5hw8G-4htzA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
3 / 3 HIS A 660
HIS A 656
HIS A 700
ZN  A1001 (-3.4A)
None
None
1.02A 5oexA-4htzA:
undetectable
5oexA-4htzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 875
THR A 805
HIS A 773
LEU A 780
None
1.28A 6gbnA-4htzA:
undetectable
6gbnA-4htzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 875
THR A 805
HIS A 773
LEU A 780
None
1.29A 6gbnD-4htzA:
undetectable
6gbnD-4htzA:
20.83