SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 8 ASP A 331
ASP A 333
TRP A 334
HIS A 111
 None
None
CTT  A 401 ( 3.8A)
CTT  A 401 (-3.7A)
 1.20A 1pk2A-4hu0A:
undetectable		 1pk2A-4hu0A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 7 SER A  79
ASP A 331
TRP A 334
GLU A 289
 None
None
CTT  A 401 ( 3.8A)
CTT  A 401 (-2.9A)
 1.05A 2cdqB-4hu0A:
undetectable		 2cdqB-4hu0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4hu0 CELLULASE
(uncultured
bacterium) 		3 / 3 ARG A  89
SER A  91
TYR A 345
 None
None
GOL  A 404 ( 4.8A)
 1.01A 2q2hA-4hu0A:
undetectable
2q2hB-4hu0A:
undetectable		 2q2hA-4hu0A:
16.81
2q2hB-4hu0A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4hu0 CELLULASE
(uncultured
bacterium) 		6 / 12 ASN A 192
GLU A 193
HIS A 258
TYR A 260
GLU A 289
TRP A 328
 CTT  A 401 (-2.8A)
CTT  A 401 (-2.8A)
None
CTT  A 401 (-4.3A)
CTT  A 401 (-2.9A)
CTT  A 401 (-3.8A)
 0.64A 2v3dA-4hu0A:
6.8		 2v3dA-4hu0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4hu0 CELLULASE
(uncultured
bacterium) 		5 / 11 ASN A 192
GLU A 193
TYR A 260
GLU A 289
TRP A 328
 CTT  A 401 (-2.8A)
CTT  A 401 (-2.8A)
CTT  A 401 (-4.3A)
CTT  A 401 (-2.9A)
CTT  A 401 (-3.8A)
 0.72A 2v3dB-4hu0A:
3.2		 2v3dB-4hu0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 8 ASN A  77
SER A  79
PHE A  95
ASN A 134
 None
 1.23A 2wekB-4hu0A:
undetectable		 2wekB-4hu0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hu0 CELLULASE
(uncultured
bacterium) 		3 / 3 ALA A 270
ARG A 274
LYS A 241
 None
 1.00A 3kp5B-4hu0A:
undetectable		 3kp5B-4hu0A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 7 GLU A 289
VAL A 326
VAL A 256
ARG A 107
 CTT  A 401 (-2.9A)
None
None
None
 1.07A 3kp6B-4hu0A:
undetectable		 3kp6B-4hu0A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 8 TYR A 292
LEU A 338
PHE A 354
TYR A 260
 None
None
None
CTT  A 401 (-4.3A)
 1.33A 3po7A-4hu0A:
undetectable		 3po7A-4hu0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4hu0 CELLULASE
(uncultured
bacterium) 		5 / 11 GLN A 157
PHE A 197
GLY A 149
ALA A 237
ALA A 232
 CTT  A 401 (-3.1A)
CTT  A 401 (-4.8A)
None
None
None
 1.19A 3sufC-4hu0A:
undetectable		 3sufC-4hu0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4hu0 CELLULASE
(uncultured
bacterium) 		3 / 3 PHE A 318
TYR A 260
TYR A 310
 None
CTT  A 401 (-4.3A)
None
 0.87A 4ffwA-4hu0A:
undetectable		 4ffwA-4hu0A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 7 LYS A  48
TRP A 133
TYR A 179
VAL A 130
 None
 1.13A 4l64A-4hu0A:
8.2		 4l64A-4hu0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4hu0 CELLULASE
(uncultured
bacterium) 		3 / 3 ASP A 144
VAL A 185
ASN A  77
 None
 0.79A 4lmnA-4hu0A:
undetectable		 4lmnA-4hu0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 5 ASN A 192
HIS A 146
GLU A 189
THR A 288
 CTT  A 401 (-2.8A)
CTT  A 401 (-3.7A)
None
None
 1.42A 4p6sA-4hu0A:
undetectable		 4p6sA-4hu0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 6 THR A 164
GLY A 166
GLU A 167
PHE A 169
 None
 0.92A 5kmfA-4hu0A:
undetectable
5kmfC-4hu0A:
undetectable		 5kmfA-4hu0A:
21.24
5kmfC-4hu0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 5 HIS A 146
ASP A  80
ASP A  85
ARG A 107
 CTT  A 401 (-3.7A)
None
None
None
 1.32A 5w7pA-4hu0A:
0.4		 5w7pA-4hu0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)		 4hu0 CELLULASE
(uncultured
bacterium) 		4 / 5 TYR A 123
HIS A 146
ASP A  80
ASP A  85
 None
CTT  A 401 (-3.7A)
None
None
 1.33A 5w7pA-4hu0A:
0.4		 5w7pA-4hu0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4hu0 CELLULASE
(uncultured
bacterium) 		3 / 3 THR A 288
GLU A 189
HIS A 146
 None
None
CTT  A 401 (-3.7A)
 0.89A 5xioA-4hu0A:
undetectable		 5xioA-4hu0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4hu0 CELLULASE
(uncultured
bacterium) 		3 / 3 THR A 288
GLU A 189
HIS A 146
 None
None
CTT  A 401 (-3.7A)
 0.83A 5xiqB-4hu0A:
undetectable		 5xiqB-4hu0A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4hu0 CELLULASE
(uncultured
bacterium) 		3 / 3 THR A 288
GLU A 189
HIS A 146
 None
None
CTT  A 401 (-3.7A)
 0.85A 5xiqD-4hu0A:
undetectable		 5xiqD-4hu0A:
20.50