SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4hu2 PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  75
TYR A 229
VAL A 101
VAL A  79
 None
 1.31A 2y05A-4hu2A:
undetectable
2y05B-4hu2A:
undetectable		 2y05A-4hu2A:
21.43
2y05B-4hu2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4hu2 PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 243
ARG A 173
ILE A 178
THR A 245
 None
 1.24A 3cl9A-4hu2A:
undetectable		 3cl9A-4hu2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4hu2 PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  79
GLY A 230
GLN A 117
THR A 145
VAL A  73
 None
 1.14A 6czmA-4hu2A:
undetectable
6czmB-4hu2A:
undetectable		 6czmA-4hu2A:
18.33
6czmB-4hu2A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4hu2 PROBABLE CONSERVED
LIPOPROTEIN LPPS
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  79
GLY A 230
GLN A 117
THR A 145
VAL A  73
 None
 1.11A 6czmB-4hu2A:
undetectable
6czmC-4hu2A:
undetectable		 6czmB-4hu2A:
18.33
6czmC-4hu2A:
18.33