SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4hu3 OXYGEN SENSOR
PROTEIN DOSP
(Escherichia
coli) 		5 / 9 ILE A 719
VAL A 756
GLY A 755
ALA A 753
LEU A 765
 None
 1.07A 1e7bA-4hu3A:
undetectable		 1e7bA-4hu3A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 4hu3 OXYGEN SENSOR
PROTEIN DOSP
(Escherichia
coli) 		4 / 5 ILE A 575
TRP A 622
LEU A 572
PRO A 630
 None
 1.25A 1s8fA-4hu3A:
undetectable
1s8fB-4hu3A:
undetectable		 1s8fA-4hu3A:
19.29
1s8fB-4hu3A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4hu3 OXYGEN SENSOR
PROTEIN DOSP
(Escherichia
coli) 		4 / 8 GLY A 755
GLU A 754
ALA A 753
ILE A 773
 None
 0.79A 2dtjA-4hu3A:
undetectable
2dtjB-4hu3A:
undetectable		 2dtjA-4hu3A:
18.34
2dtjB-4hu3A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4hu3 OXYGEN SENSOR
PROTEIN DOSP
(Escherichia
coli) 		5 / 11 VAL A 634
LEU A 646
ILE A 595
VAL A 611
ILE A 612
 None
 1.19A 2uxoB-4hu3A:
undetectable		 2uxoB-4hu3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4hu3 OXYGEN SENSOR
PROTEIN DOSP
(Escherichia
coli) 		4 / 8 LEU A 636
MET A 690
MET A 654
LEU A 664
 None
 0.94A 4ok1A-4hu3A:
undetectable		 4ok1A-4hu3A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 4hu3 OXYGEN SENSOR
PROTEIN DOSP
(Escherichia
coli) 		4 / 5 VAL A 756
GLU A 754
VAL A 752
LYS A 718
 None
 1.38A 4p6vB-4hu3A:
undetectable
4p6vE-4hu3A:
undetectable		 4p6vB-4hu3A:
20.75
4p6vE-4hu3A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4hu3 OXYGEN SENSOR
PROTEIN DOSP
(Escherichia
coli) 		5 / 12 VAL A 794
ILE A 787
LEU A 572
TYR A 573
ALA A 631
 None
 1.33A 5fctB-4hu3A:
undetectable		 5fctB-4hu3A:
20.19